★ 20190828


★ 20190125


Tear-Free Gold Leaves Made of Nanofibers and Gold Nanoparticles

★ 20180926


Electrochemical detection of viable bacterial cells using a Tetrazolium salt- a novel technique achieving up to 10,000-fold higher in sensitivity than the limit of detection!

★ 20180405

金ナノ粒子による色変化で細菌の生物機能を評価 -細菌の生存度を目視でリアルタイムに測定-

Real-Time Evaluation of Bacterial Viability Using Gold Nanoparticles

★ 20180307

人工抗体の形成による特異結合型マイクロウェルプレートの開発 -用途に合わせテーラーメイドで迅速に標的細菌を検出-

Preparation of 1-3 dimensional nanoarchitectures




Application of nanoarchitectures


New strategies that involve a combination of nanomaterials and nanofabrication techniques have been developed in the field of electronics. We developed a green electroless plating technique through a self-assembling between metal nanoparticles (MNPs) and a nontoxic binder. This technique allows a uniform surface coating and thickness reflected by the diameter of AuNPs on the micrometer-sized structures, and enables saving resources and reduction in emissions to the environment.

Chem. Commun. 2003, 1038-1039

J. Electrochem. Soc. 160, H630-H635 (2013)

Anal. Chem. 86, 4977-4981 (2014)

ChemNanoMat 5, 581-585 (2019)


The detection of DNA hybridization is important in the diagnosis of genetic diseases, DNA mapping, and forensic identification. We have developed a nano-gapped electrode by using a molecular electronic technology. The nano-gapped electrode leads us to detect very small electrical signal without labels. We have succeeded in observing the hybridization directly, focusing on the electrical properties of DNA.

Nano Lett. 3, 1391-1394 (2003)

J. Am. Chem. Soc. 127, 3280-3281 (2005)

Anal. Chem. 80, 8071-8075 (2008)

J. Am. Chem. Soc. 135, 5238-5241 (2013)

Chem. Commun. 53, 5212-5215 (2017)


Pathogenic bacteria, cause widespread hospital-acquired infections and food poisoning, are a major public health problem worldwide. Since nanobioscience is one of the major areas of scientific progress, it should create important advances that benefit human health. We have developed a simple manipulation of gold nanoparticles that creates a structure-dependent nanometer-scale antenna on the surface of bacteria. Our studies illuminate the concept of the "effective use of light" based on the absorption and emission of light by antennas.

Chem. Commun. 50, 6252-6255 (2014)

Chem. Commun. 50, 11887-11890 (2014)

Anal. Chem. 87, 4042-4046 (2015)

Anal. Chem. 90, 4098-4103 (2018)

Molecular imprinting

We have found a new way to circumvent these problems of standard molecularly imprinted polymer (MIP) synthetic procedures. The overoxidized polypyrrole (PPy) indicates unique and attractive features for molecular recognition. We have succeeded in sensing a variety of biomolecules (amino acids, ATP, chole acids, peptides, viruses and microorganisms) as the overoxidized PPy used for the detection platform.

Anal. Chem. 74, 4184-4190 (2002)

J. Electrochem. Soc. 152, H129-123 (2005)

Anal. Chem. 85, 4925-4929 (2013)

Anal. Chem. 89, 4680-4684 (2017)

Chem. Commun. 53, 3890-3893 (2017)

Bacterial platform

We have developed successfully an immobilization of living bacteria into the conducting polymers such as polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT). The bacteria-doped conducting polymer films is useful for bioanalysis, since it is possible for us to observe a proliferative process and various metabolism of bacterium by electrochemical and microscopic measurements. By efficiently using functions of bacteria themselves, we have considered the applications of platform to a various field such as sensing, creation of energy, and production of useful substances.

Anal. Chem. 87, 4047-4052 (2015)

Anal. Chem. 87, 8416-8423 (2015)

Anal. Chem. 90, 10641-11168 (2018)

Anal. Chem. 90, 10641-11168 (2019)