TOP PAGE　＞　研究内容（３）　＞　遺伝子ベクターに関する原著論文と総説

遺伝子ベクターに関する原著論文と総説

S. Iwashita, Y. Hiramatsu, T. Otani, C. Amano, M. Hirai, H. Minematsu, H. Kitagawa, K. Oie, E. Yuba, K. Kono, M. Miyamoto, K. Igarashi, "Assemblies of polyamidoamine dendron-bearing lipids with various generations: their morphologies and abilities of gene transfection", J. Biomaterials Applications, 27, 445-456 (2012).
E. Yuba, Y. Nakajima, K. Tsukamoto, S. Iwashita, C. Kojima, A. Harada, K. Kono, "Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine)dendron-bearing lipids", J. Control. Release, 160, 552-560 (2012).
K. Kono, R. Ikeda, K. Tsukamoto, E. Yuba, C. Kojima, A. Harada, "Polyamidoamine dendron-bearing lipids as a non-viral vector: influence of dendron generation", Bioconjugate Chem., 23, 871-879 (2012).
A. Harada, Y. Kimura, K. Kono, "Cationic polymers with inhibition ability of DNA condensation elevate gene expression", ChemBioChem, 11, 1985-1988 (2010).
T. Takahashi, E. Yuba, C. Kojima, A. Harada, K. Kono, "Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors", Res. Chemical Intermediates, 35, 1005-1014 (2009).
A. Harada, M. Kawamura, Y. Kimura, T. Takahashi, C. Kojima, K. Kono, "Effect of head size in head-tail type polycations on their in vitro performances as non-viral gene vectors", Macromol. Biosci., 9, 605-612 (2009).
N. Sakaguchi, C. Kojima, A Harada, K. Koiwai, K. Kono, "The correlation between fusion capability and transfection activity in hybrid complexes of lipoplexes and pH-sensitive liposomes", Biomaterials, 29, 4029-4036 (2008).
N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, N. Emi, K. Kono, "Effect of transferrin as a ligand of pH-sensitive fusogenic liposome-lipoplex hybrid complexes", Bioconjugate Chem., 19, 1588-1595 (2008).
E. Yuba, C. Kojima, N. Sakaguchi, A. Harada, K. Koiwai, K. Kono, "Gene delivery to dendritic cells mediated by complexes of lipoplexes and pH-sensitive fusogenic polymer-modified liposomes", J. Control. Release, 130, 77-83 (2008).
N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution", Biomaterials, 29, 1262-1272 (2008).
T. Takahashi, J. Hirose, C. Kojima, A. Harada, K. Kono, "Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors", Bioconjugate Chem., 18, 1163-1169 (2007).
河野健司，児島千恵，「機能性リポソームによる遺伝子の細胞内デリバリー」，バイオプロセスハンドブック，pp. 13-20 (2007), エヌ・ティー・エス．
T. Takahashi, C. Kojima, A. Harada, K. Kono, "Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector", Bioconjugate Chem., 18, 1349-1354 (2007).
N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Enhancement of transfection activity of lipoplexes by complexation with transferrin-bearing fusogenic polymer-modified liposomes", Int. J. Pharm., 325, 186-190 (2006).
河野健司，「機能性リポソームによる遺伝子の細胞内送達」，高分子，55, 330-333 (2006). （総説）
A. Harada, M. Kawamura, T. Matsuo, T. Takahashi, K. Kono, "Synthesis and characterization of head-tail type polycation block copolymer as non-viral gene vector", Bioconjugate Chem., 17, 3-5 (2006).
T. Takahashi, A. Harada, N. Emi, K. Kono, "Preparation of efficient gene carriers using a polyamidoamine dendron-bearing lipid: improvement of serum resistance", Bioconjugate Chem., 16, 1160-1165 (2005).
K. Kono, H. Akiyama, T. Takahashi, T. Takagishi, A. Harada, "Transfection activity of polyamidoamine dendrimers having hydrophobic amino acid residues in the periphery", Bioconjugate Chem., 16, 208-214 (2005).
T. Takahashi, K. Kono, T. Itoh, N. Emi, T. Takagishi, "Synthesis of novel cationic lipids having polyamidoamine dendrons and their transfection activity", Bioconjugate Chem., 14, 764-773 (2003).
K. Kono, T. Takagishi, "Fusogenic polymer-modified liposomes for the delivery of genes and charged fluorophores", Methods in Enzymology, 373, 422-432 (2003).
河野健司，「高効率遺伝子デリバリーを目指した機能性ベクターの設計」，インテリジェント材料・システム，12 (2), 9-14 (2003).
K. Kono, Y. Torikoshi, M. Mitsutomi, T. Itoh,N. Emi, H. Yanagie, T. Takagishi, "Novel gene delivery systems: complexes of fusogenic polymer-modified liposomes and lipoplexes", Gene Therapy, 8, 5-12 (2001).
K. Kono, M. Iwamoto, R. Nishikawa, H. Yanagie, T. Takagishi, "Design of fusogenic liposomes using a poly(ethylene glycol) derivative having amino groups", J. Control. Release, 68, 225-235 (2000).

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