TOP PAGE　＞　研究内容（２－ｂ）　＞　膜融合性リポソームに関する原著論文と総説

膜融合性リポソームに関する原著論文と総説

E. Yuba, A. Harada, Y. Sakanishi, K. Kono, "Carboxylated hyperbranched poly(glycidol)s for preparation of pH-sensitive liposomes", J. Control. Release, 149, 72-80 (2011).
E. Yuba, C. Kojima, A. Harada, Tana, S. Watarai, K. Kono, "pH-Sensitive fusogenic polymer-modified liposomes as a carrier of antigenic proteins for activation of cellular immunity", Biomaterials, 31, 943-951 (2010).
L. T. Ng, E. Yuba, K. Kono, "Modification of liposome surface with ph-responsive polyampholytes for the controlled-release of drugs", Res. Chemical Intermediates, 35, 1015-1025 (2009).
C. Kojima, Y. Hirano, K. Kono, "Preparation of complexes of liposomes with gold nanoparticles", Methods in Enzymology, 464, 131-145 (2009).
河野健司，「精密デリバリーを目指したリポソームの機能化」，Progress in Drug Delivery System，18, 11-16 (2009).
河野健司，弓場英司，「細胞内で機能するリポソーム」，未来材料，9 (3), 12-19 (2009).
N. Sakaguchi, C. Kojima, A Harada, K. Koiwai, K. Kono, "The correlation between fusion capability and transfection activity in hybrid complexes of lipoplexes and pH-sensitive liposomes", Biomaterials, 29, 4029-4036 (2008).
N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, N. Emi, K. Kono, "Effect of transferrin as a ligand of pH-sensitive fusogenic liposome-lipoplex hybrid complexes", Bioconjugate Chem., 19, 1588-1595 (2008).
E. Yuba, C. Kojima, N. Sakaguchi, A. Harada, K. Koiwai, K. Kono, "Gene delivery to dendritic cells mediated by complexes of lipoplexes and pH-sensitive fusogenic polymer-modified liposomes", J. Control. Release, 130, 77-83 (2008).
N. Sakaguchi, C. Kojima, A. Harada, K. Kono, "Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: their ability to sensitize stable liposomes to pH", Bioconjugate Chem., 19, 1040-1048 (2008).
N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution", Biomaterials, 29, 1262-1272 (2008).
N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Enhancement of transfection activity of lipoplexes by complexation with transferrin-bearing fusogenic polymer-modified liposomes", Int. J. Pharm., 325, 186-190 (2006).
K. Kono, "Stimuli responsive polymer-liposomes: formulation and in vitro evaluation", MML Series Vol. 7, K. Kono, R. Arshady (Eds.), Kentus Books, London , 91-123 (2006).
河野健司，「機能性リポソームによる遺伝子の細胞内送達」，高分子，55, 330-333 (2006). （総説）
河野健司，「膜融合性リポソーム」，リポソーム応用の新展開，秋吉一成，辻井薫　監修，pp 576-585 (2005), エヌ・ティー・エス．
K. Kono, T. Takagishi, "Fusogenic polymer-modified liposomes for the delivery of genes and charged fluorophores", Methods in Enzymology, 373, 422-432 (2003).
T. Mizoue, T. Horibe, K. Maruyama, T. Takizawa, M. Iwatsuru, K. Kono, H. Yanagie, F. Moriyasu, "Targetability and intracellular delivery of anti-BCG antibody-modified, pH-sensitive fusogenic immunoliposomes to tumor cells", Int. J. Pharm., 237, 129-137 (2002).
K. Kono, Y. Torikoshi, M. Mitsutomi, T. Itoh,N. Emi, H. Yanagie, T. Takagishi, "Novel gene delivery systems: complexes of fusogenic polymer-modified liposomes and lipoplexes", Gene Therapy, 8, 5-12 (2001).
K. Kono, M. Iwamoto, R. Nishikawa, H. Yanagie, T. Takagishi, "Design of fusogenic liposomes using a poly(ethylene glycol) derivative having amino groups", J. Control. Release, 68, 225-235 (2000).
河野健司，「高分子修飾による機能性リポソームの設計とドラッグデリバリーシステムへの応用」，生体材料，18, 107-112 (2000). （総説）
K. Katayama, T. Takizawa, K. Maruyama, M. Iwatsuru, K. Kono, "Fusogenic immunoliposomes modified by pH sensitive PEG derivatives", Prog. Drug Delivery System, VII, 29-38 (1998).
K. Kono, T. Igawa, T. Takagishi, "Cytoplasmic delivery of calcein mediated by liposomes modified with a pH-sensitive poly(ethylene glycol) derivative", Biochim. Biophys. Acta, 1325, 143-154 (1997).
K. Kono, T. Igawa, T. Takagishi, "Novel pH-sensitive liposomes: preparation of liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups and their application to drug delivery systems", in Biomedical Functions and Biotechnology of Natural and Artificial Polymers, M. Yalpani (Ed.), ATL Press, Shrewsbury, 181-192 (1996).
K. Kono, T. Takagishi, "Cytoplasmic delivery mediated by liposomes modified with a fusogenic polymer", Trans. Mater. Res. Soc. Jpn., 20, 17-20 (1996).
K. Kono, K. Zenitani, T. Takagishi, "Novel pH-sensitive liposomes: liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups", Biochim. Biophys. Acta, 1193, 1-9 (1994).
K. Kono, H. Nishii, T. Takagishi, "Fusion activity of an amphiphilic polypeptide having acidic amino acid residues: generation of fusion activity bya-helix formation and charge neutralization", Biochim. Biophys. Acta, 1164, 81-90 (1993).
河野健司，高岸徹，「ドラッグデリバリーシステムへの応用のためのリポソームの機能化」，生体材料，11, 238-245 (1993). （総説）

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