原田敦史
氏名 原田  敦史(はらだ あつし) 部屋 B5棟 5階 5A - 02
TEL&FAX 072-254-9328 Email
学歴 東京理科大学基礎工学部材料工学科卒業(1994)
東京理科大学大学院博士前期課程修了(1996)
東京理科大学大学院博士後期課程中退(1998)
博士取得(東京大学)(2002)
職歴 日本学術振興会特別研究員(DC2)(1998)
東京大学大学院工学系研究科材料学専攻助手(1998)
東京大学大学院工学系研究科マテリアル工学専攻助手(2002)
大阪府立大学大学院工学研究科機能物質科学分野講師(2003)
大阪府立大学大学院工学研究科応用化学分野助教授(2005)
大阪府立大学大学院工学研究科応用化学分野准教授(2007)
大阪府立大学大学院工学研究科応用化学分野教授(2018)
学位 工学博士(東京大学 2002)
学位論文:"Structural Design of Novel Supramolecular Assembly from Charged
Block Copolymers and Its Utilities as Functional Materials"
所属学会 高分子学会,日本バイオマテリアル学会,日本化学会,日本DDS学会
American Chemical Society,Controlled Release Society

原著論文・総説 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995   著書 1996~2020

原著論文・総説

2021

  • 152) E. Yuba, T. Korenaga, A. Harada, “Hydrophilic hyperbranched polymer-coated siRNA/polyamidoamine dendron-bearing lipid complexes preparation for high colloidal stability and efficient RNAi”, Bioconjugate Chemistry, , in press. DOI:

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2007

  • 67) A. Harada, K. Johnin, A. Kawamura, K. Kono, Preparation of temperature-responsive polymer gels physically immobilizing core-shell type bioconjugates, J. Polym. Sci. Part A: Polym. Chem., 2007, 45 (24), 5942-5948
  • 66) A. Kawamura, A. Harada, K. Kono, K. Kataoka, Self-assembled nano-bioreactor from block ionomers with elevated and stabilized enzymatic function, Bioconjugate Chem., 2007, 18 (5), 1555-1559
  • 65) K. Kono, T. Miyoshi, Y. Haba, E. Murakami, C. Kojima, A. Harada, Temperature sensitivity control of alkylamide-terminated poly(amidoamine) dendrimers induced by guest molecule binding, J. Am. Chem. Soc., 2007, 129 (23), 7222-7223
  • 64) T. Takahashi, J. Hirose, C. Kojima, A. Harada, K. Kono, Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors, Bioconjugate Chem., 2007, 18 (4), 1163-1169
  • 63) T. Takahashi, C. Kojima, A. Harada, K. Kono, Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector, Bioconjugate Chem., 2007, 18 (4), 1349-1354
  • 62) Y. Haba, C. Kojima, A. Harada, T. Ura, H. Horinaka, K. Kono, Preparation of poly(ethylene glycol)-modified poly(amidoamine) dendrimers encapsulating gold nanoparticles and their heat-generating ability, Langmuir, 2007, 23 (10), 5243-5246
  • 61) C. Kojima, Y. Toi, A. Harada, K. Kono, Preparation of polyethylene glycol-attached dendrimers encapsulating photosensitizers for application to photodynamic therapy, Bioconjugate Chem., 2007, 18 (3), 663-670
  • 60) 原田敦史・片岡一則,ナノバイオデバイスとして機能する高分子ミセル設計,オレオサイエンス,2007, 7 (3), 111-118
  • 59) A. Harada, Y. Yoshioka, A. Kawamura, C. Kojima, K. Kono, "Effect of polycarboxylate block on the amidase activity of trypsin through complexation with peg-polycarboxylate block ionomers", Macromol. Biosci., 2007, 7 (3), 339-343
  • 58) Y. Haba, C. Kojima, A. Harada, K. Kono, Comparison of thermosensitive properties between poly(amidoamine) dendrimers having peripheral N-isopropylamide groups and linear polymers with the same groups, Angew. Chem. Int. Ed., 2007, 46 (1-2), 234-237

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2006

  • 57) A. Harada, K. Kataoka, Supramolecular assemblies of block copolymers in aqueous media as nanocontainers relevant to biological applications, Prog. Polym. Sci., 2006, 31 (11), 949-982
  • 56) A. Harada, K. Kataoka, Stimuli responsive polyion complex assemblies, MML Series 7, Smart Nano and Microparticles, K. Kono, R. Arshady (eds.), 2006, pp. 210-229, Kentus Books, London
  • 55) Y. Haba, C. Kojima, A. Harada, K. Kono, Control of temperature-sensitive properties of poly(amidoamine) dendrimers using peripheral modification with various alkylamide groups, Macromolecules, 2006, 39 (21), 7451-7453
  • 54) 原田敦史,遺伝子ベクターとしてのヘッド-テイル型ポリカチオンブロック共重合体の分子設計,バイオマテリアル,2006, 24 (3), 171-175
  • 53) N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, Enhancement of transfection activity of lipoplexes by complexation with transferrin-bearing fusogenic polymer-modified liposomes, Int. J. Pharm., 2006, 325 (1-2), 186-190
  • 52) Y. Tono, C. Kojima, Y. Haba, T. Takahashi, A. Harada, S. Yagi, K. Kono, Thermosensitive properties of poly(amidoamine) dendrimers with peripheral phenylalanine residues, Langmuir, 2006, 22 (11), 4920-4922
  • 51) A. Harada, M. Kawamura, T. Matsuo, T. Takahashi, K. Kono, Synthesis and characterization of head-tail type polycation block copolymer as non-viral gene vector, Bioconjugate Chem., 2006, 17 (1), 3-5

2005

  • 50) T. Takahashi, A. Harada, N. Emi, K. Kono, Preparation of efficient gene carriers using a polyamidoamine dendron-bearing lipid: improvement of serum resistance, Bioconjugate Chem., 2005, 16 (5), 1160-1165
  • 49) A. Kawamura, Y. Yoshioka, A. Harada, K. Kono, Acceleration of enzymatic reaction of trypsin through the formation of water-soluble complexes with poly(ethylene glycol)-block-poly(α, β-aspartic acid), Biomacromolecules, 2005, 6 (2), 627-631
  • 48) X. Yuan, A. Harada, Y. Yamasaki, K. Kataoka, Stabilization of Lysozyme-Incorporated Polyion Complex (PIC) Micelle by the ω-End-Derivatization of Poly(ethylene glycol)-Poly(α, β-aspartic acid) Block Copolymer with Various Hydrophobic Groups, Langmuir, 2005, 21 (7), 2668-2674
  • 47) Y. Haba, A. Harada, T. Takagishi, K. Kono, Synthesis of biocompatible dendrimers with a peripheral network formed by linking of polymerizable groups, Polymer, 2005, 46 (6), 1813-1820
  • 46) K. Kono, H. Akiyama, T. Takahashi, T. Takagishi, A. Harada, Transfection Activity of Polyamidoamine Dendrimers Having Hydrophobic Amino Acid Residues in the Periphery, Bioconjugate Chem., 2005, 16 (1), 208-214
  • 45) W.-D. Jang, N. Nishiyama, G.-D. Zhang, A. Harada, D.-L. Jiang, S. Kawauci, Y. Morimoto, M. Kikuchi, H. Koyama, T. Aida, K. Kataoka, Suparmolecular nanocarrier of anionic dendrimer porphyrins with PEGylated cationic block copolymer to enhance intracellular photodynamic efficacy, Angew. Chem. Int. Ed., 2005, 44 (3), 419-423

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2004

  • 44) 原田敦史,内核に酵素反応場を有するコア-シェル型ナノ組織体の調製とバイオナノリアクターとしての機能,高分子加工2004, 53 (12), 12-16
  • 43) D. Wakebayashi, N. Nishiyama, K. Itaka, K. Miyata, Y. Yamasaki, A. Harada, H. Koyama, Y. Nagasaki, K. Kataoka, Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as gene carrier systems: Physicochemical properties of micelles relevant to gene transfection efficacy, Biomacromolecules, 2004, 5 (6), 2128-2136
  • 42) Y. Haba, A. Harada, T. Takagishi, K. Kono, Rendering poly(amidoamine) or poly(propylenimine) dendrimers temperature sensitive, J. Am. Chem. Soc., 2004, 126 (40), 12760-12761
  • 41) H. Katakura, A. Harada, K. Kataoka, M. Furusho, F. Tanaka, H. Wada, K. Ikenaka, Improvement of retroviral vectors by coating with poly(ethylene glycol) - poly(L-lysine) block copolymer (PEG-PLL), J. Gene Med., 2004, 6 (4), 471-477
  • 40) K. Miyata, Y. Kakizawa, N. Nishiyama, A. Harada, Y. Yamasaki, K. Kataoka, H. Koyama, Block Catiomer Polyplexes with Regulated Densities of Charge and Disulfide Crosslinking Directed to Enhanced Gene Expression, J. Am. Chem. Soc., 2004, 126 (8), 2355-2361
  • 39) D. Wakebayashi, N. Nishiyama, Y. Yamasaki, K. Itaka, N. Kanayama, A. Harada, Y. Nagasaki, K. Kataoka, Lactose-installed polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: Their preparation and gene transfecting efficiency against cultured HepG2 cells, J. Control. Release, 2004, 95 (3), 653-664
  • 38) M. Jaturanpinyo, A. Harada X. Yuan, K. Kataoka, Preparation of Bionanoreactor Based on Core-Shell Structured Polyion Complex Micelles Entrapping Trypsin in the Core Cross-Linked with Glutaraldehyde, Bioconjuguate Chem., 2004, 15 (2), 344-348
  • 37) K. Itaka, A. Harada, Y. Yamasaki, K. Nakamura, H. Kawaguchi, K. Kataoka, In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic deliveryand easy release of plasmid DNA complexed with linear polyethylenimine, J. Gene Med., 2004, 6 (1), 76-84
  • 36) R. Ideta, Y. Yanagi, Y. Tamaki, F. Tasaka, A. Harada K. Kataoka, Effective accumulation of polyion complex micelle to experimental choroidal neovascularization in rats, FEBS Lett., 2004, 557 (1-3), 21-25

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2003

  • 35) G.-D. Zhang, A. Harada, N. Nishiyama, D.-L. Jiang, H. Koyama, T. Aida, K. Kataoka, Polyion complex micelles entrapping cationic dendrimer porphyrin: Effective photosensitizer for photodynamic therapy of cancer, J. Control. Release, 2003,93 (2), 141-150
  • 34) A. Harada, K. Kataoka, Switching by Pulse Electric Field of the Elevated Enzymatic Reaction in the Core of Polyion Complex Micelles, J. Am. Chem. Soc., 2003, 125 (50), 15306-15307
  • 33) K. Itaka, K. Yamauchi, A. Harada, K. Nakamura, H. Kawaguchi, K. Kataoka, Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: Physicochemical properties of micelles relevant to gene transfection efficiency, Biomaterials, 2003, 24 (24), 4495-4506
  • 32) Y. Bae, S. Fukushima, A. Harada, K. Kataoka, Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: The polymeric micelles responsive to intracellular pH change, Angew. Chem. Int. Ed., 2003, 42 (38), 4640-4643
  • 31) A. Matsumoto, S. Ikeda, A. Harada, K. Kataoka, Totally Synthetic Glucose Responsive Polymer Bearing a Novel Phenylborate Derivative as a Glucose-Sensing Moiety Operating at Physiological pH Condition, Biomacromolecules, 2003, 4 (5), 1410-1416
  • 30) Y. S. Bae, S. Fukushima, A. Harada, K. Kataoka, Preparation and characterization of pH responsive adriamycin-loaded polymeric micelles: Drug release profile and in vitro cytotoxicity on human lung cancer SBC-3, J. Control. Release, 2003, 91 (1-2), 237-239
  • 29) A. Harada, K. Kataoka, Effect of charged segment length on physicochemical properties of core-shell type polyion complex micelles from block ionomers, Macromolecules, 2003, 36 (13), 4995-5001
  • 28) G.-D. Zhang, N. Nishiyama, A. Harada, D.-L. Jiang, T. Aida, K. Kataoka, pH-sensitive assembly of light-harvesting dendrimer zinc porphyrin bearing periphery groups of primary amine with poly(ethylene glycol)-b-poly(aspartic acid) in aqueous solution, Macromolecules, 2003, 36 (4), 1304-1309

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2002

  • 27) Y. Yamamoto, K. Yasugi, A. Harada, Y. Nagasaki, K. Kataoka, , Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles in aqueous milieu, J. Control. Release, 2002, 82 (2-3), 359-371
  • 26) K. Itaka, A. Harada, K. Nakamura, H. Kawaguchi, K. Kataoka, Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions, Biomacromolecules, 2002, 3 (4), 841-845
  • 25) M. Harada-Shiba, K. Yamauchi, A. Harada, I. Takamisawa, K. Shimokado, K. Kataoka, Polyion complex micelles as vectors in gene therapy - pharmacokinetics and in vivo gene transfer, Gene Therapy, 2002, 9 (6), 407-414

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2001

  • 24) Y. Nagasaki, K. Yasugi, Y. Yamamoto, A. Harada, K. Kataoka, Sugar-installed block copolymer micelles: Their preparation and specific interaction with lectin molecules, Biomacromolecules, 2001, 2 (4), 1067-1070
  • 23) 原田敦史・片岡一則,高分子ミセルを基盤とした多機能型遺伝子ベクターの開発,医学のあゆみ2001, 199 (11-12), 756-760
  • 22) 片岡一則・原田敦史,メディカル・フロンティアに向けてのインテリジェントポリマー設計,高分子2001, 50 (7), 442-445
  • 21) Y. Kakizawa, A. Harada, K. Kataoka, Glutathione-sensitive stabilization of block copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-block-poly(L-lysine): A potential carrier for systemic delivery of antisense DNA, Biomacromolecules, 2001, 2 (2), 491-497
  • 20) A. Harada, K. Kataoka, Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymers, J. Control. Release, 2001, 72 (1-3), 85-91
  • 19) A. Harada, H. Togawa, K. Kataoka, Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)-poly(L-lysine) block copolymers, Eur. J. Pharmaceut. Sci., 2001, 13 (1), 35-42
  • 18) K. Kataoka, A. Harada, Y. Nagasaki, Block copolymer micelles for drug delivery: design, characterization and biological significance, Adv. Drug Delivery Rev., 2001, 47 (1), 113-131
  • 17) A. Harada, K. Kataoka, Polyion complex micelles with core-shell structure: their physicochemical properties and utilities as functional materials, Macromol. Symp., 2001, 172 (Polymers in Medicine), 1-9

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2000

  • 16) Y. Akiyama, A. Harada, Y. Nagasaki, K. Kataoka, Synthesis of poly(ethylene glycol)-block-poly(ethylenimine) possessing an acetal group at the PEG end, Macromolecules, 2000, 33 (16), 5841-5845
  • 15) 柿澤資訓・原田敦史・片岡一則,環境応答的に解離するアンチセンスDNA内包ポリイオンコンプレックスミセル,インテリジェント材料2000, 10 (1), 11-13
  • 14) 原田敦史・片岡一則,ウイルス構造に啓発されたドラッグデリバリー用デバイスの創製,蛋白質・核酸・酵素2000, 45 (7), 1265-1272
  • 13) S. Cammas-Marion, M.-M. Bear, A. Harada, P. Guerin, K. Kataoka, New macromolecular micelles based on degradable amphiphilic block copolymers of malic acid and malic acid ester, Macromol. Chem. Phys., 2000, 201 (3), 355-364

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1999

  • 12) Y. Kakizawa, A. Harada, K. Kataoka, Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond, J. Am. Chem. Soc., 1999, 121 (48), 11247-11248
  • 11) K. Kataoka, A. Harada, D. Wakebayashi, Y. Nagasaki, Polyion complex micelles with reactive aldehyde groups on their surface from plasmid DNA and end-functionalized charged block copolymers, Macromolecules, 1999, 32 (20), 6892-6894
  • 10) A. Harada, K. Kataoka, On-off control of enzymatic activity synchronizing with reversible formation of supramolecular assembly from enzyme and charged block copolymers, J. Am. Chem. Soc., 1999, 121 (39), 9241-9242
  • 9) A. Harada, K. Kataoka, Novel polyion complex micelles entrapping enzyme molecules in the core. 2. Characterization of the micelles prepared at nonstoichiometric mixing ratios, Langmuir, 1999, 15 (12), 4208-4212
  • 8) A. Harada, K. Kataoka, Chain length recognition: Core-shell supramolecular assembly from oppositely charged block copolymers, Science, 1999, 283 (5398), 65-67

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1998

  • 7) K. Kataoka, A. Ishihara, A. Harada, H. Miyazaki, Effect of the secondary structure of poly(L-lysine) segments on the micellization in aqueous milieu of poly(ethylene glycol)-poly(L-lysine) block copolymer partially substituted with a hydrocinnamoyl group at the Ne-position, Macromolecules, 1998, 31 (18), 6071-6076
  • 6) A. Harada, K. Kataoka, Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium, Macromolecules, 1998, 31 (2), 288-294

1997

  • 5) A. Harada, K. Kataoka, Formation of stable and monodispersive polyion complex micelles in aqueous medium from poly(L-lysine) and poly(ethylene glycol)-poly(aspartic acid) block copolymer, J. Macromol. Sci. Pure. Appl. Chem., 1997, A34 (10), 2119-2133

1996

  • 4) A. Harada, S. Cammas, K. Kataoka, Stabilized a-helix structure of poly(L-lysine)-block-poly(ethylene glycol) in aqueous medium through supramolecular assembly, Macromolecules, 1996, 29 (19), 6183-6188
  • 3) S. Cammas, A. Harada, Y. Nagasaki, K. Kataoka, Poly(ethylene oxide-co-b-benzyl L-aspartate) block copolymers: Influence of the poly(ethylene oxide) block on the conformation of the poly(b-benzyl L-aspartate) segment in organic solvents, Macromolecules, 1996, 29 (9), 3227-3231
  • 2) K. Kataoka, H. Togawa, A. Harada, K. Yasugi, T. Matsumoto, S. Katayose, Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline, Macromolecules, 1996, 29 (26), 8556-8557

1995

  • 1) A. Harada, K. Kataoka, Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments, Macromolecules, 1995, 28 (15), 5294-5299

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著書

  • 11) 河野健司,原田敦史, 「医療応用のための材料化学」, 医療・診断・創薬の化学 -医療分野に挑む革新的な科学技術-, 28-35 (2017) 化学同人.
  • 10) 原田敦史, 「酵素と多相系高分子からなる酵素内包コアシェル型ナノ組織体」, コアシェル微粒子の設計・合成技術・応用の展開, pp. 215-223 (2010), シーエムシー.
  • 9) 原田敦史,「バイオコンジュゲートを用いた機能性ゲルの創製」,医療用ゲルの最新技術と開発,pp. 108-114 (2008), シーエムシー.
  • 8) 原田敦史,「ナノバイオデバイスとして機能する高分子ミセル」,次世代医療のための高分子材料工学,pp. 1-10 (2008), シーエムシー.
  • 7) 原田敦史,内核に酵素反応場を有するコア-シェル型ナノ組織体,酵素の活用・利用の最新技術,2006, シーエムシー,第4編第3章
  • 6) 原田敦史,機能化高分子ナノミセル,ソフトナノテクノロジー-バイオマテリアル革命,2005, シーエムシー,230-235
  • 5) 原田敦史・片岡一則,酵素内包コア-シェル型ナノ微粒子の外部刺激による酵素機能制御,ナノバイオエンジニアリングマテリアル,2004, フロンティア出版,209-215
  • 4) 片岡一則・山崎裕一・大塚英典・原田敦史,メディカルナノテクノロジー,ナノテクノロジー基礎シリーズ バイオナノテクノロジー,2003, オーム社,169-197
  • 3) 原田敦史・片岡一則,高分子ミセルと遺伝子治療,先端化学シリーズ3 糖鎖/バイオマテリアル/分子認識/バイオインフォマティクス,2003, 丸善,198-204
  • 2) 原田敦史・片岡一則,高分子ナノミセルによるDDS,図解ナノテク活用技術のすべて,2002, ㈱工業調査会,282-285
  • 1) A. Harada, K. Kataoka, Formation of core-shell type nano-associates through electrostatic interaction between peptide and block copolymer with polyethylene glycol segment, Adv. Biomater. Biomed. Eng. Drug Delivery Syst., [5th Iketani Conf. Biomed. Polym.], 1996, 317-318

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