TOP PAGE　＞　研究業績

Recent Publications

2021

• E. Yuba, T. Korenaga, A. Harada, “Hydrophilic hyperbranched polymer-coated siRNA/polyamidoamine dendron-bearing lipid complexes preparation for high colloidal stability and efficient RNAi”, Bioconjugate Chemistry, , in press. DOI:
• E. Yuba, Y. Sugahara, Y. Yoshizaki, T. Shimizu, M. Kasai, K. Udaka, K. Kono, “Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses”, Biomaterials Science, , in press. DOI:10.1039/D0BM01813A
• I. Nakase, N. Ueno, M. Matsuzawa, K. Noguchi, M. Hirano, M. Omura, T. Takenaka, A. Sugiyama, N. B. Kobayashi, T. Hashimoto, T. Takatani‐Nakase, E. Yuba, I. Fujii, S. Futaki, T. Yoshida, “Environmental pH stress influences cellular secretion and uptake of extracellular vesicles”, FEBS Openbio., , in press. DOI:10.1002/2211-5463.13107

2020

• H. Setiawan, E. Yuba, A. Harada, I. Aoki, K. Kono, “Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics”, Nano Select, , in press. DOI:10.1002/nano.202000218
• 弓場英司, "pH応答性高分子とリポソームを基盤とした免疫誘導システムの開発", Drug Delivery System, 35, 426-433 (2020).
• E. Yuba, E. Budina, K. Katsumata, A. Ishihara, A. Mansurov, A. T. Alpar, E. A. Watkins, P. Hosseinchi, J. W. Reda, A. L. Lauterbach, M. Nguyen, A. Solanki, T. Kageyama, M. A. Swartz, J. Ishihara, J. A. Hubbell, “Enhanced lymph node trafficking of engineered IL-10 suppresses rheumatoid arthritis in murine models”, Arthritis Rheumatol., , in press. DOI:10.1002/art.41585
• A. Ishihara, J. Ishihara, E. A. Watkins, A. C. Tremain, M. Nguyen, A. Solanki, K. Katsumata, A. Mansurov, E. Budina, A. T. Alpar, P. Hosseinchi, L. Maillat, J. W. Reda, T. Kageyama, M. A. Swartz, E. Yuba, J. A. Hubbell, “Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis”, Nat. Biomed. Eng., ,in press. DOI:10.1038/s41551-020-00627-3
• E. Yuba, Y. Fukaya, S. Yanagihara, N. Kasho, A. Harada, “Development of mannose-modified carboxylated curdlan-coated liposomes for antigen presenting cell targeted antigen delivery”, Pharmaceutics, 12, 754 (2020). DOI:10.3390/pharmaceutics12080754
• T. Hashimoto, Y. Hirai, E. Yuba, A. Harada, K. Kono, “Temperature-responsive molecular assemblies using oligo(ethylene glycol)-attached polyamidoamine dendron lipids and their functions as drug carriers”, J. Funct. Biomater., 11, 16 (2020). DOI:10.3390/jfb11010016
• T. Hashimoto, T. Hirata, E. Yuba, A. Harada, K. Kono, “Light-activatable transfection system using hybrid vectors composed of thermosensitive dendron lipids and gold nanorods”, Pharmaceutics, 12, 239 (2020). DOI:10.3390/pharmaceutics12030239
• T. Hashimoto, E. Yuba, A. Harada, K. Kono, “Preparation of photothermal-chemotherapy nanohybrids by complexation of gold nanorods with polyamidoamine dendrimers having poly(ethylene glycol) and hydrophobic chains”, J. Mater. Chem. B, 8, 2826-2833 (2020). DOI:10.1039/C9TB02163A
• B. Gupta, D. Sadaria, V. U. Warrier, A. Kirtonia, R. Kant, A. Awasthi, P. Baligar, J. K. Pal, E. Yuba, G. Sethi, M. Garg, R. K. Gupta, “Plant lectins and their usage in preparing targeted nanovaccines for cancer immunotherapy”, Semin. Cancer Biol., , in press. (Review) DOI:10.1016/j.semcancer.2020.02.005
• E. Yuba, “Development of functional liposomes by modification of stimuli-responsive materials and their biomedical applications”, J. Mater. Chem. B, 8, 1093-1107 (2020). (Review) DOI:10.1039/C9TB02470K

2019

• K. Katsumata, J. Ishihara, K. Fukunaga, A. Ishihara, E. Yuba, E. Budina, J. A. Hubbell, "Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis", Arthritis Res. Ther., 21, 298 (2019). DOI: 10.1186/s13075-019-2075-8.
• D. P. H. Wijesekera, E. Yuba, N. H. De Silva, S. Watanabe, M. Tsukamoto, C. Ichida, T. Izawa, K. Itoh, R. Kanegi, S. Hatoya, J. Yamate, T. Inaba, K. Sugiura, "Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy", FASEB BioAdvances, 2, 5-17 (2020). DOI: 10.1096/fba.2019-00052.
• K. Noguchi, M. Hirano, T. Hashimoto, E. Yuba, T. Takatani-Nakase, I. Nakase, "Effects of lyophilization of arginine-rich cell-penetrating peptide-modified extracellular vesicles on intracellular delivery", Anticancer Research, 39, 6701-6709 (2019). DOI:10.21873/anticanres.13885.
• M. Miyazaki, E. Yuba, H. Hayashi, A. Harada, K. Kono, "Development of pH-responsive hyaluronic acid-based antigen carriers for induction of antigen-specific cellular immune responses", ACS Biomaterials Science & Engineering, 5, 5790-5797 (2019). DOI: 10.1021/acsbiomaterials.9b01278.
• K. Katsumata, J. Ishihara, A. Mansurov, A. Ishihara, M. M. Raczy, E. Yuba, J. A. Hubbell, "Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies", Science Advances, 5, eaay1971 (2019). DOI: 10.1126/sciadv.aay1971.
• V. U. Warrier, A. I. Makandar, M. Garg, G. Sethi, R. Kant, J. K. Pal, E. Yuba, R. K. Gupta, "Engineering anti-cancer nanovaccine based on antigen cross-presentation", Biosc. Rep., 39, BSR20193220 (2019). DOI: 10.1042/BSR20193220.
• 弓場英司, "pH応答性高分子を基盤とした免疫誘導システムの設計", Drug Delivery System, 34, 163-172 (2019).
• M. Okubo, M. Miyazaki, E. Yuba, A. Harada, "Chondroitin sulfate-based pH-sensitive polymer-modified liposomes for intracellular antigen delivery and induction of cancer immunity", Bioconjugate Chemistry, 30, 1518-1529 (2019). DOI: 10.1021/acs.bioconjchem.9b00221.
• A. Harada, K. Nomura, E. Yuba, K. Kono, "Gene expression of aspect ratio-controlled polyplexes based on the effect of multi-arm poly(ethylene glycol)", ACS Biomaterials Science & Engineering, 5, 5681-5687 (2019). DOI: 10.1021/acsbiomaterials.8b01498.
• S. Kaviarasi, E. Yuba, A. Harada, U. M. Krishnan, "Emerging paradigms in nanotechnology for imaging and treatment of cerebral ischemia", J. Control. Release, 300, 22-45 (2019). DOI: 10.1016/j.jconrel.2019.02.031.
• S. Kaviarasi, K. S. S. Devi, P. Vinoth, V. Sridharan, E. Yuba, A. Harada, U. M. Krishnan, “Synthesis, characterization, and biomedical applications of an alkylated quercetin–gadolinium complex”, ACS Biomaterials Science & Engineering, 5, 1215-1227 (2019). DOI: 10.1021/acsbiomaterials.8b01254.
• R. Teranishi, T. Matsuda, E. Yuba, K. Kono, A. Harada, "Sonodynamic therapeutic effects of sonosensitizers with different intracellular distribution delivered by hollow nanocapsules exhibiting cytosol specific release", Macromolecular Bioscience, 19, e1800365 (2019). DOI: 10.1002/mabi.201800365.
• S. Kuroyanagi, N. Shimada, S. Fujii, T. Furuta, A. Harada, K. Sakurai, A. Maruyama, “Highly ordered polypeptide with UCST phase-separation behavior”, Journal of the American Chemical Society, 141, 1261-1268 (2019). DOI: 10.1021/jacs.8b10168.
• 弓場英司, "免疫づくり", 高分子, 68, 75 (2019).

2018

• 弓場英司， 「pH応答性リポソームの設計とDDS応用」, 刺激応答性高分子ハンドブック, 497-506 (2018) エヌ・ティー・エス．
• E. Yuba, “Stimuli-responsive polymer-modified liposomes and their application to DDS”, In "Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications”, Elsevier, Vol. 2, 305-319 (2018).
• 弓場英司， 「機能性分子の表面修飾による刺激応答性リポソームの創製とそのバイオ応用」, 粉体の表面処理・複合化技術集大成-基礎から応用まで-，423-431 (2018) テクノシステム．
• 弓場英司, 「pH応答性多糖とリポソームを基盤とした免疫誘導システムの開発」, 高分子論文集, 75, 433-443 (2018). DOI: 10.1295/koron.2018-0013.
• 弓場英司， 「機能性高分子の表面修飾による細胞特異的リポソームDDSの設計」, J. Soc. Powder Technol., Japan, 55, 389-396 (2018). DOI: 10.4164/sptj.55.389.
• 弓場英司， 「抗原-サイトカイン同時デリバリーシステムの構築とナノワクチンの創製」, ドラッグデリバリーシステム-バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発-，138-146 (2018) シーエムシー．
• E. Yuba, “Liposome-based immunity-inducing systems for cancer immunotherapy”, Molecular Immunology, 98, 8-12 (2018). (Review) DOI: 10.1016/j.molimm.2017.11.001.
• 藤原大佑，弓場英司，白石一乗，中瀬生彦，藤井郁雄， 「ポスト抗体医薬品：立体構造規制ペプチド「マイクロ抗体」を土台とした中分子創薬」, MEDCHEM NEWS, 28, 83-87 (2018).
• 山本聡, 古川和樹, 小野雅文, 弓場英司, 原田敦史, 河野健司， 「TiO₂ナノ粒子内包ポリイオンコンプレックスミセルによる疎水性プロドラッグの可溶化と超音波照射効果」, 高分子論文集, 75, 42-47 (2018). DOI: 10.1295/koron.2017-0063.
• X. Li, K. Kono, “Functional dendrimer–gold nanoparticle hybrids for biomedical applications”, Polymer International, 67, 840-852 (2018). DOI: 10.1002/pi.5583.
• M. Miyazaki, E. Yuba, H. Hayashi, A. Harada, K. Kono, “Hyaluronic acid-based pH-sensitive polymer-modified liposomes for cell-specific intracellular drug delivery systems”, Bioconjugate Chem., 29, 44-55 (2018). DOI: 10.1021/acs.bioconjchem.7b00551.
• E. Yuba, T. Osaki, M. Ono, S. Park, A. Harada, M. Yamashita, K. Azuma, T. Tsuka, N. Ito, T. Imagawa, Y. Okamoto, “Bleomycin-loaded pH-sensitive polymer-lipid-incorporated liposomes for cancer chemotherapy”, Polymers, 10, 74 (2018). DOI: 10.3390/polym10010074. [Open Access]
• M. Tsuruta, S. Ueda, P.Y. Yew, I. Fukuda, S. Yoshimura, H. Kishi, H. Hamana, M. Hirayama, J. Yatsuda, A. Irie, S. Senju, E. Yuba, T. Kamba, M. Eto, H. Nakayama, Y. Nishimura, “Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro”, OncoImmunology, 7, e1415687 (2018). DOI: 10.1080/2162402X.2017.1415687.
• A. Harada, K. Kataoka, “Polyion complex micelle (PIC micelle) formation from double-hydrophilic block copolymers composed of charged and non-charged segments in aqueous medium”, Polymer Journal, 50, 95-100 (2018). DOI: 10.1038/pj.2017.67. [Free Access]
• 弓場英司，原田敦史， 「DDS応用を指向した刺激応答性リポソームの設計」, ファルマシア, 54, 11-15 (2018). DOI: 10.14894/faruawpsj.54.1_11.
• S. Okazaki, T. Iwasaki, E. Yuba, S. Watarai, “Evaluation of pH-sensitive fusogenic polymer-modified liposomes co-loaded with antigen and α-galactosylceramide as an anti-tumor vaccine”, J. Vet. Med. Sci., 80, 197-204 (2018). DOI: 10.1292/jvms.17-0491. [Free Access]
• S. Uchida, N. Yoshinaga, K. Yanagihara, E. Yuba, K. Kataoka, K. Itaka, “Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination”, Biomaterials, 150, 162-170 (2018). DOI: 10.1016/j.biomaterials.2017.09.033.
• N. Yamazaki, S. Yamakawa, T. Sugimoto, Y. Yoshizaki, R. Teranishi, T. Hayashi, A. Kotaka, C. Shinde, T. Kumei, Y. Sumida, T. Shimizu, Y. Ohashi, E. Yuba, A. Harada, K. Kono, “Carboxylated phytosterol derivative-introduced liposomes for skin environment-responsive transdermal drug delivery system”, J. Liposome Res., 28, 275-284 (2018). DOI: 10.1080/08982104.2017.1369995.

2017

• E. Yuba, N. Sakaguchi, Y. Kanda, M. Miyazaki, K. Koiwai, “pH-responsive micelle-based cytoplasmic delivery system for induction of cellular immunity”, Vaccines, 5, 41 (2017). DOI: 10.3390/vaccines5040041. [Open Access]
• S. Yamamoto, M. Ono, E. Yuba, A. Harada, “In vitro sonodynamic therapeutic effect of polyion complex micelles incorporating titanium dioxide nanoparticles”, Nanomaterials, 7, 268 (2017). DOI: 10.3390/nano7090268. [Open Access]
• 河野健司，原田敦史， 「医療応用のための材料化学」, 医療・診断・創薬の化学 －医療分野に挑む革新的な科学技術－, 28-35 (2017) 化学同人.
• A. Hirano, T, Hashimoto, D. Kitagawa, K. Kono, S. Kobatake, “Dependence of photoinduced bending behavior of diarylethene crystals on ultraviolet irradiation power”, Crystal Growth & Design, 17, 4819-4825 (2017). DOI: 10.1021/acs.cgd.7b00755.
• E. Yuba, S. Uesugi, M. Miyazaki, Y. Kado, A. Harada, K. Kono, “Development of pH-sensitive dextran derivatives with strong adjuvant function and their application to antigen delivery”, Membranes, 7, 41 (2017). DOI: 10.3390/membranes7030041. [Open Access]
• Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono, “pH-sensitive polymer-modified liposome-based immunity-inducing system: effects of inclusion of cationic lipid and CpG-DNA”, Biomaterials, 141, 272-283 (2017). DOI: 10.1016/j.biomaterials.2017.07.001.
• 弓場英司， 「がん免疫療法用の抗原デリバリーシステム開発」, DDS先端技術の製剤への応用開発, 270-282 (2017) 技術情報協会.
• 弓場英司， 「高分子と脂質の構造をもつデンドロン脂質ベクターの開発と活性評価」, DDS先端技術の製剤への応用開発, 304-312 (2017) 技術情報協会.
• Y. Inaba, K. Watanabe, M. Kitamatsu, E. Nakata, A. Harada, T. Ohtsuki, “Ultrasound-dependent cytoplasmic internalization of a peptide-sonosensitizer conjugate”, Bioorganic & Medicinal Chemistry, 25, 4212-4217 (2017). DOI: 10.1016/j.bmc.2017.06.024.
• A. Harada, R. Teranishi, E. Yuba, K. Kono, “Effect of the side chain spacer structure on the pH-responsive properties of polycarboxylates”, Journal of Biomaterials Science: Polymer Edition, 28, 1025-1035 (2017). DOI: 10.1080/09205063.2017.1324551.
• E. Yuba, S. Uesugi, Y. Yoshizaki, A. Harada, K. Kono, “Potentiation of cancer immunity-inducing effect by pH-sensitive polysaccharide-modified liposomes with combination of TGF-β type I receptor inhibitor-embedded liposomes”, Med. Res. Arch., 5, (2017). DOI: 10.18103/mra.v5i5.1243. [Open Access]
• T．Sugimoto, N. Yamazaki, T. Hayashi, E. Yuba, A. Harada, A. Kotaka, C. Shinde, T. Kumei, Y. Sumida, M. Fukushima, Y. Munekata, K. Maruyama, K. Kono, “Preparation of dual-stimuli-responsive liposomes using methacrylate-based copolymers with pH and temperature sensitivities for precisely controlled release”, Colloids Surf. B: Biointerfaces, 155, 449-458 (2017). DOI: 10.1016/j.colsurfb.2017.04.043.
• D. Kokuryo, I. Aoki, E. Yuba, K. Kono, S. Aoshima, J. Kershaw, T. Saga, “Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon-ion irradiation”, Translational Research, 185, 24-33 (2017). DOI: 10.1016/j.trsl.2017.04.001. [Open Access]
• N. Yamazaki, T. Sugimoto, M. Fukushima, R. Teranishi, A. Kotaka, C. Shinde, T. Kumei, Y. Sumida, Y. Munekata, K. Maruyama, E. Yuba, A. Harada, K. Kono, “Dual-stimuli responsive liposomes using pH- and temperature-sensitive polymers for controlled transdermal delivery”, Polymer Chemistry, 8, 1507-1518 (2017). DOI: 10.1039/c6py01754a.
• R. Teranishi, R. Matsuki, E. Yuba, A. Harada, K. Kono, “Doxorubicin delivery using pH and redox dual-responsive hollow nanocapsules with a cationic electrostatic barrier”, Pharmaceutics, 9, 4 (2017). DOI: 10.3390/pharmaceutics9010004. [Open Access]
• E. Yuba, A. Yamaguchi, Y. Yoshizaki, A. Harada, K. Kono, “Bioactive polysaccharide-based pH-sensitive polymers for cytoplasmic delivery of antigen and activation of antigen-specific immunity”, Biomaterials, 120, 32-45 (2017). DOI: 10.1016/j.biomaterials.2016.12.021.
• Y. Shimizu, T. Iwasaki, T. Tajima, E. Yuba, K. Kono, S. Watarai, “Induction of antibody response in the oral cavity of dogs following intraocular (eye drop) immunization with Porphyromonas gingivalis cell lysate incorporated in pH-sensitive fusogenic polymer-modified liposomes”, J. Vet. Med. Sci., 79, 290-298 (2017). DOI: 10.1292/jvms.16-0338.

2016

• Y. Yoshizaki, E. Yuba, T. Komatsu, K. Udaka, A. Harada, K. Kono, “Improvement of peptide-based tumor immunotherapy using pH-sensitive fusogenic polymer-modified liposomes”, Molecules, 21, 1284 (2016). DOI:10.3390/molecules21101284. [Open Access]
• 河野健司, "リポソームエンジニアリング：高機能化・高性能化への挑戦", Drug Delivery System, 31, 331-342 (2016).
• D. Fujiwara, H. Kitada, M. Oguri, T. Nishihara, M. Michigami, K. Shiraishi, E. Yuba, I. Nakase, H. Im, S. Cho, J. Y. Joung, S. Kodama, K. Kono, S. Ham, I. Fujii, “A cyclized helix-loop-helix peptide as a molecular scaffold for the design of inhibitors of intracellular protein-protein interactions by epitope and arginine grafting”, Angew. Chem. Int. Ed., 128, 10770-10773 (2016). DOI:10.1002/ange.201603230.
• 弓場英司，原田敦史, 河野健司, 「免疫治療のためのDDS最前線」, 高分子, 65, 435-440 (2016).
• Y. Xu, M. Shinoyama, A. Harada, “Soft matter-regulated active nanovalves locally self-assembled in femtoliter nanofluidic channels”, Advanced Materials, 28, 2209-2216 (2016). DOI:10.1002/adma.201505132.
• S. A. Chechetka, E. Yuba, K. Kono, M. Yudasaka, A. Bianco, E. Miyako, “Magnetically- and near infrared light-powered supramolecular nanotransporters for the remote control of enzymatic reactions”, Angew. Chem. Int. Ed., 55, 6476-6481 (2016). DOI: 10.1002/anie.201602453 and 10.1002/ange.201602453.
• E. Yuba, “Design of pH-sensitive polymer-modified liposomes for antigen delivery and their application in cancer immunotherapy”, Polymer Journal, 48, 761-771 (2016). DOI:10.1038/pj.2016.31.
• M. Hirayama, Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, Y. Imamura, M. A. Sayem, A. Irie, Y. Yoshitake, D. Fukuma, M. Shinohara, A. Hamada, H. Jono, E. Yuba, K. Kono, K. Yoshida, T. Tsunoda, H. Nakayama, Y. Nishimura, “An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs”, OncoImmunology, 5, e1123368 (2016). DOI:10.1080/2162402X.2015.1123368. [Open Access]
• M. A. Sayem, Y. Tomita, A. Yuno, M. Hirayama, A. Irie, H. Tsukamoto, S. Senju, E. Yuba, T. Yoshikawa, K. Kono, T. Nakatsura, Y. Nishimura, “Identification of glypican-3-derived long peptides activating both CD8+ and CD4+ T-cells; prolonged overall survival in cancer patients with Th cell response”, OncoImmunology, 5, e1062209 (2016). DOI: 10.1080/2162402X.2015.1062209. [Open Access]

2015

• I. Aoki, M. Yoneyama, J. Hirose, Y. Minemoto, T. Koyama, D. Kokuryo, R. Bakalova, S. Murayama, T. Saga, S. Aoshima, Y. Ishizaka, K. Kono, “Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy", Translational Research, 166, 660-673 (2015). DOI: 10.1016/j.trsl.2015.07.009.
• E. Miyako, S. A. Chechetka, M. Doi, E. Yuba, K. Kono, “In vivo remote control of reactions in Caenorhabditis elegans by using supramolecular nanohybrids of carbon nanotubes and liposomes", Angew. Chem. Int. Ed., 54, 9903-9906 (2015). DOI: 10.1002/anie.201504987.
• 弓場英司, 河野健司, 「ポリマー修飾」, DDSキャリア作製プロトコル集, pp. 42-52 (2015) シーエムシー.
• 河野健司, 弓場英司, 「デンドリマー」, DDSキャリア作製プロトコル集, pp. 89-98 (2015) シーエムシー.
• K. Kono, M. Takashima, E. Yuba, A. Harada, Y. Hiramatsu, H. Kitagawa, T. Otani, K. Maruyama, S. Aoshima, “Multifunctional liposomes having target specificity, temperature-triggered release, and near-infrared fluorescence imaging for tumor-specific chemotherapy”, J. Control. Release, 216, 69-77 (2015). DOI: 10.1016/j.jconrel.2015.08.005.
• S. Yamamoto, E. Yuba, A. Harada, K. Kono, "Effective condensation of multivalent anions into polyion complex micelles prepared from TiO₂ nanoparticles and polyallylamine bearing poly(ethylene glycol) grafts", Langmuir, 31, 8583-8588 (2015). DOI: 10.1021/acs.langmuir.5b01883.
• E. Yuba, Y. Kanda, Y. Yoshizaki, R. Teranishi, A. Harada, K. Sugiura, T. Izawa, J. Yamate, N. Sakaguchi, K. Koiwai, K. Kono, “pH-Sensitive polymer-liposome-based antigen delivery systems potentiated with interferon-γ gene lipoplex for efficient cancer immunotherapy”, Biomaterials, 67, 214-224 (2015). DOI: 10.1016/j.biomaterials.2015.07.031.
• T. Doura, M. Yamada, R. Teranishi, Y. Yamamoto, T. Sugimoto, E. Yuba, A. Harada, K. Kono, "PAMAM dendron lipid assemblies that undergo structural transition in response to weakly acidic pH and their cytoplasmic delivery capability", Langmuir, 31, 5105-5114 (2015). DOI: 10.1021/acs.langmuir.5b00183.
• R. Aono, K. Nomura, E. Yuba, A. Harada, K. Kono , "Gene expression of ternary complexes through the compaction of nanofiber-polyplexes by mixing with Lipofectamine", Biomaterials Science, 3, 764-770 (2015). DOI: 10.1039/C5BM00081E.
• 弓場英司, "pH応答性高分子を基盤としたがん免疫治療用抗原デリバリーシステムの設計", Drug Delivery System, 30, 160-161 (2015).
• X. Li, Y. Watanabe, E. Yuba, A. Harada, T. Haino, K. Kono, "Facile construction of well-defined fullerene-dendrimer supramolecular nanocomposites for bioapplications", Chem. Commun., 51, 2851-2854 (2015). DOI: 10.1039/C4CC09082A.
• D. Kokuryo, S. Nakashima, F. Ozaki, E. Yuba, K. H. Chuang, S. Aoshima, Y. Ishizaka, T. Saga, K. Kono, I. Aoki, "Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI", Nanomedicine-Nanotechnology, Biology and Medicine, 11, 229-238 (2015). DOI: 10.1016/j.nano.2014.09.001.

2014

• K. Kono, T. Kaiden, E. Yuba, Y. Sakanishi, A. Harada, "Synthesis of oligoethylene glycol-modified hyperbranched polyglycidols for dual sensitization of liposomes to pH and temperature", J. Taiwan Institute of Chemical Engineers, 45, 3054-3061 (2014). DOI：10.1016/j.jtice.2014.06.011.
• D. P. H. Wijesekera, K. Sugiura, E. Yuba, K. Ueda, V. Wijewardana, R. Kanegi, T. Nishimura, T. Ushigusa, S. Hatoya, K. Kono, T. Inaba, “Enhancement of anti-tumor immune responses by transfection of IFNγ gene into tumor using a novel type synthetic vector”, Veterinary Immunology and Immunopathology, 162, 59-64 (2014). DOI: 10.1016/j.vetimm.2014.08.016.
• Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono, “Potentiation of pH-sensitive polymer-modified liposomes with cationic lipid inclusion as antigen delivery carriers for cancer immunotherapy”, Biomaterials, 35, 8186-8196 (2014). DOI:10.1016/j.biomaterials.2014.05.077.
• K. Kono, K. Takeda, X. Li, E. Yuba, A. Harada, T. Ozaki, S. Mori, "Dually functionalized dendrimers by temperature-sensitive surface modification and gold nanoparticle loading for biomedical application", RSC Adv., 4, 27811-27819 (2014). DOI: 10.1039/c4ra03947e.
• X. Li, K. Takeda, E. Yuba, A. Harada, K. Kono, “Preparation of PEG-modified PAMAM dendrimers having gold nanorod core and their application to photothermal therapy”, J. Mater. Chem. B, 2, 4167-4176 (2014). DOI:10.1039/C4TB00132J.
• X. Li, M. Takashima, E. Yuba, A. Harada, K. Kono, “PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy”, Biomaterials, 35, 6576-6584 (2014). DOI:10.1016/j.biomaterials.2014.04.043.
• R. Aono, E. Yuba, A. Harada, K. Kono, "Nanofiber polyplex formation based on the morphology elongation by the intra-polyplex PEG crowding effect", ACS Macro Lett., 3, 333-336 (2014). DOI: 10.1021/mz500072k.
• S. Watarai, T. Iwase, T. Tajima, E. Yuba, K. Kono, Y. Sekiya, "Application of pH-sensitive fusogenic polymer-modified liposomes for development of mucosal vaccines", Veterinary Immunology and Immunopathology, 158, 62-72 (2014). DOI:10.1016/j.vetimm.2013.05.005.
• E. Yuba, K. Kono, "Nasal delivery of biopharmaceuticals", In "Mucosal Delivery of Biopharmaceuticals", pp.197-220, Springer Science, New York (2014). DOI:10.1007/978-1-4614-9524-6_8.
• 弓場英司, 「がん免疫治療用抗原デリバリーシステムとしてのpH応答性ポリマー修飾リポソーム」, バイオマテリアル-生体材料-, 32(1), 42-44 (2014).
• E. Yuba, N. Tajima, Y. Yoshizaki, A. Harada, H. Hayashi, K. Kono, "Dextran derivative-based pH-sensitive liposomes for cancer immunotherapy", Biomaterials, 35, 3091-3101 (2014). DOI:10.1016/j.biomaterials.2013.12.024.

2013

• 弓場英司, 「pH応答性ポリマー修飾リポソームを用いた抗原デリバリーとがん免疫治療への応用」, Major Histocompatibility Complex, 20, 181-189 (2013). DOI:10.12667/mhc.20.181. [Free Access]
• C. Kojima, E. Nishisaka, T. Suehiro, K. Watanabe, A. Harada, T. Goto, Y. Magata, K. Kono, "The synthesis and evaluation of polymer prodrug/collagen hybrid gels for delivery into metastatic cancer cells", Nanomedicine-Nanotechnology, Biology and Medicine, 9, 767-775 (2013). DOI:10.1016/j.nano.2013.01.004.
• A. Harada, R. Matsuki, S. Ichimura, E. Yuba, K. Kono, "Intracellular environment-responsive stabilization of polymer vesicles formed from head-tail type polycations composed of polyamidoamine dendron and poly (L-lysine)", Molecules, 18, 12168-12179 (2013). DOI:10.3390/molecules181012168. [Open Access]
• 弓場英司, 河野健司, 「バイオ機能リポソームと免疫治療」, 化学, 68, 66-67 (2013).
• C. Kojima, H. Kawabata, A. Harada, H. Horinaka, K. Kono, "Design of a novel drug carrier with photo-responsive properties: drug-encapsulated and alkanethiol-modified gold nanoparticle-loaded PEGylated dendrimer", Chem. Lett., 42, 612-614 (2013). DOI:10.1246/cl.130079.
• E. Yuba, Y. Kono, A. Harada, S. Yokoyama, M. Arai, K. Kubo, K. Kono, "The application of pH-sensitive polymer-lipids to antigen delivery for cancer immunotherapy", Biomaterials, 34, 5711-5721 (2013). DOI:10.1016/j.biomaterials.2013.04.007.
• X. Li, Y. Haba, K. Ochi, E. Yuba, A. Harada, K. Kono, "PAMAM dendrimers with oxyethylene unit-enriched surface as biocompatible temperature-sensitive dendrimers", Bioconjugate Chem., 24, 282-290 (2013). DOI:10.1021/bc300190v.
• S. Watarai, T. Iwase, T. Tajima, E. Yuba, K. Kono, "Efficiency of pH-sensitive fusogenic polymer-modified liposomes as a vaccine carrier", Scientific World J., 2013, 903234 (2013). DOI:10.1155/2013/903234. [Open Access]
• E. Yuba, A. Harada, Y. Sakanishi, S. Watarai, K. Kono, "A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy", Biomaterials, 34, 3042-3052 (2013). DOI:10.1016/j.biomaterials.2012.12.031.
• C. Kojima, T. Suehiro, K. Watanabe, M. Ogawa, A. Fukuhara, E. Nishisaka, A. Harada, K. Kono, T. Inui, Y. Magata, "Doxorubicin-conjugated dendrimer/collagen hybrid gels for metastasis-associated drug delivery system”, Acta Biomaterialia, 9, 5673-5680 (2013). DOI:10.1016/j.actbio.2012.11.013.
• A. Harada, M. Ono, E. Yuba, K. Kono, "Titanium dioxide nanoparticles-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy", Biomaterials Science, 1, 65-73 (2013). DOI: 10.1039/C2BM00066K.

2012

• S. Iwashita, Y. Hiramatsu, T. Otani, C. Amano, M. Hirai, K. Oie, E. Yuba, K. Kono, M. Miyamoto, K. Igarashi, "Polyamidoamine dendron-bearing lipid assemblies:Their morphologies and gene transfection ability", J. Biomaterials Applications, 27, 445-456 (2012). DOI:10.1177/0885328211411955.
• E. Miyako, K. Kono, E. Yuba, C. Hosokawa, H. Nagai, Y. Hagihara, "Carbon nanotube-liposome supramolecular nanotrains for intelligent molecular-transport systems", Nature Commun., 3, 1226 (2012). DOI:10.1038/ncomms2233. [Open Access]
• T. Hebishima, E. Yuba, K. Kono, S. Takeshima, Y. Ito, Y. Aida, “The pH-sensitive fusogenic 3-methyl-glutarylated hyperbranched poly(glycidol) (MGlu-HPG)-conjugated liposome induces antigen-specific cellular and humoral immunity”, Clinical and Vaccine Immunology, 19, 1492-1498 (2012). DOI:10.1128/CVI.00273-12. [Free Access]
• K. Kono, "Dendrimer-based bionanomaterials produced by surface modification, assembly, and hybrid formation", Polymer Journal, 44, 531-540 (2012). DOI:10.1038/pj.2012.39.
• E. Yuba, Y. Nakajima, K. Tsukamoto, S. Iwashita, C. Kojima, A. Harada, K. Kono, "Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids", J. Control. Release, 160, 552-560 (2012). DOI:10.1016/j.jconrel.2012.04.002.
• T. Koyama, M. Shimura, Y. Minemoto, S. Nohara, S. Shibata, Y. Iida, S. Iwashita, M. Hasegawa, T. Kurabayashi, H. Hamada, K. Kono, E. Honda, I. Aoki, and Y. Ishizaka, "Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide", J. Control. Release, 159, 413-418 (2012). DOI:10.1016/j.jconrel.2012.01.023.
• 河野健司, 「機能性デンドリマーとＤＤＳ」, 先端バイオマテリアル, pp. 347-357 (2012) エヌ・ティー・エス．
• K. Kono, R. Ikeda, K. Tsukamoto, E. Yuba, C. Kojima, A. Harada, "Polyamidoamine dendron-bearing lipids as a non-viral vector: influence of dendron generation", Bioconjugate Chem., 23, 871-879 (2012). DOI:10.1021/bc200368b.
• 片桐清文, 河野健司, 青島貞人 「外部シグナルに応答して内包物を放出する有機－無機ハイブリッドカプセル」, 機能材料, 32, 14-21 (2012). (総説）
• K. Yoshino, K. Taguchi, M. Mochizuki, S. Nozawa, H. Kasukawa, K. Kono, "Novel analytical method to evaluate the surface condition of polyethyleneglycol-modified liposomes", Colloids Surf. A: Physicochemical and Engineering Aspects, 397, 73-79 (2012). DOI:10.1016/j.colsurfa.2012.01.035.
• 弓場英司, 河野健司, 「高感度pH応答性リポソームのワクチンへの応用」, ドラッグデリバリーシステムの新展開II－核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術－, pp. 189-197 (2012) シーエムシー.

2011

• C. Kojima, B. Turkbey, M. Ogawa, M. Bernardo, C. A. S. Regino, L. H. Bryant, Jr., P. L. Choyke, K. Kono, H. Kobayashi, "Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics", Nanomedicine-Nanotechnology Biology and Medicine, 7, 1001-1008 (2011). DOI:10.1016/j.nano.2011.03.007.
• T. Kaiden, E. Yuba, A. Harada, Y. Sakanishi, K. Kono, "Dual signal-responsive liposomes for temperature-controlled cytoplasmic delivery", Bioconjugate Chem., 22(10), 1909-1915 (2011). DOI:10.1021/bc2000353.
• 河野健司, 弓場英司, 「高分子の表面修飾による機能性リポソームの設計」, 膜, 36, 183-190 (2011).
• A. Harada, T. Kato, A. Kawamura, C. Kojima, K. Kono, "Effect of enzyme modification by well-defined multi-armed poly(ethylene glycol) synthesized using polyamidoamine dendron", J. Biomaterials Science: Polymer Edition, 22(12), 1551-1591 (2011). DOI:10.1163/092050610x514557.
• K. Katagiri, Y. Imai, K. Koumoto, T. Kaiden, K. Kono, S. Aoshima, "Magnetoresponsive on-demand release of hybrid liposomes formed with Fe₃O₄ nanoparticles and thermosensitive block copolymers", Small, 7, 1683-1689 (2011). DOI:10.1002/smll.2010022180.
• K. Kono, E. Murakami, Y. Hiranaka, E. Yuba, C. Kojima, A. Harada, K. Sakurai, "Thermosensitive molecular assemblies from PAMAM dendron-based lipids", Angew. Chem. Int. Ed., 50, 6332-6336 (2011). DOI:10.1002/anie.201101007.
• A. Harada, S. Ichimura, E. Yuba, K. Kono, "Hollow nanocapsules prepared through stabilization of polymer vesicles formed from head-tail type polycations by introducing cross-linkages", Soft Matter, 7(10), 4629-4635 (2011). DOI:10.1039/c1sm05075c.
• K. Kono, S. Nakashima, D. Kokuryo, I. Aoki, H. Shimomoto, S. Aoshima, K. Maruyama, E. Yuba, C. Kojima, A. Harada, Y. Ishizaka, "Multifunctional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy", Biomaterials, 32, 1387-1395 (2011). DOI:10.1016/j.biomaterials.2010.10.050.
• E. Yuba, A. Harada, Y. Sakanishi, K. Kono, "Carboxylated hyperbranched poly(glycidol)s for preparation of pH-sensitive liposomes", J. Control. Release, 149, 72-80 (2011). DOI:10.1016/j.jconrel.2010.03.001.

2010

• A. Harada, Y. Kimura, K. Kono, "Cationic polymers with inhibition ability of DNA condensation elevate gene expression", ChemBioChem, 11, 1985-1988 (2010). DOI:10.1002/cbic.201000394.
• C. Kojima, Y. Umeda, A. Harada, K. Kono, "Preparation of near-infrared light absorbing gold nanoparticles using polyethylene glycol-attached dendrimers", Colloids Surf. B: Biointerfaces, 81, 648-651 (2010). DOI:10.1016/j.colsurfb.2010.07.060.
• C. Kojima, K. Yoshimura, A. Harada, Y. Sakanishi, K. Kono, "Temperature-sensitive hyperbranched poly(glycidol)s with oligo(ethylene glycol) monoethers", J. Polym. Sci. Part A: Polym. Chem., 48, 4047-4054 (2010). DOI:10.1002/pola.24190.
• Y. Umeda, C. Kojima, A. Harada, H. Horinaka, K. Kono, "PEG-attached PAMAM dendrimers encapsulating gold nanoparticles: growing gold nanoparticles in the dendrimers for improvement of their photothermal properties", Bioconjugate Chem., 21, 1559-1564 (2010). DOI:10.1021/bc1001399.
• 原田敦史, 「酵素と多相系高分子からなる酵素内包コアシェル型ナノ組織体」, コアシェル微粒子の設計・合成技術・応用の展開, pp. 215-223 (2010), シーエムシー．
• K. Kono, T. Ozawa, T. Yoshida, F. Ozaki, Y. Ishizaka, K. Maruyama, C. Kojima, A. Harada, S. Aoshima, "Highly temperature-sensitive liposomes based on a thermosensitive block copolymer for tumor-specific chemotherapy", Biomaterials, 31, 7096-7105 (2010). DOI:10.1016/j.biomaterials.2010.05.045.
• K. Kono, "Polymer-based nanomaterials for drug delivery", in Environmentally Harmonious Chemistry for the 21st Century, M. Anpo, K. Mizuno (Eds), pp. 149-162, Nova Science Publishers, NY (2010).
• C. Kojima, Y. Umeda, M. Ogawa, A. Harada, Y. Magata, K. Kono, "X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticle in PEGylated dendrimer", Nanotechnology, 21, 245104 (2010). DOI:10.1088/0957_4484/21/24/245104.
• A. Harada, Y. Kimura, C. Kojima, K. Kono, "Effective tolerance to serum proteins of head-tail type polycation vectors by PEGylation at the periphery of the head block", Biomacromolecules, 11, 1036-1042 (2010). DOI:10.1021/bm1000108.
• T. Suehiro, C. Kojima, S. Tsumura, A. Harada, K. Kono, "Higher order structure of short collagen model peptides attached to dendrimers and linear polymers", Biopolymers, 93, 640-648 (2010). DOI:10.1002/bip.21413.
• A. Harada, A. Yuzawa, T. Kato, C. Kojima, K. Kono, "Effect of pH and generation of dendron on single-step synthesis of gold nanoparticles using PEGylated polyamidoamine dendron in aqueous medium", J. Polym. Sci. Part A: Polym. Chem., 48, 1391-1398 (2010). DOI:10.1002/pola.23901.
• E. Yuba, C. Kojima, A. Harada, Tana, S. Watarai, K. Kono, "pH-Sensitive fusogenic polymer-modified liposomes as a carrier of antigenic proteins for activation of cellular immunity", Biomaterials, 31, 943-951 (2010). DOI:10.1016/j.biomaterials.2009.10.006.
• C. Kojima, C. Regino, Y. Umeda, H. Kobayashi, K. Kono, "Influence of dendrimer generation and polyethylene glycol length on the biodistribution of pegylated dendrimers", Int. J. Pharm., 383, 293-296 (2010). DOI:10.1016/j.ijpharm.2009.09.015.

2009

• 増永慎一郎，田野恵三，中村純，河野健司，渡邉正巳，鈴木実，菓子野元郎，木梨友子，劉勇，小野公二，「γ線照射または化学療法時に併用されるヘキサメチレンテトラミンの有用性について」, 放射線生物研究, 44, 472-482 (2009).
• L. T. Ng, E. Yuba, K. Kono, "Modification of liposome surface with ph-responsive polyampholytes for the controlled-release of drugs", Res. Chemical Intermediates, 35, 1015-1025 (2009).
• T. Takahashi, E. Yuba, C. Kojima, A. Harada, K. Kono, "Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors", Res. Chemical Intermediates, 35, 1005-1014 (2009). DOI:10.1007/s11164_009_0083_z.
• C. Kojima, Y. Hirano, K. Kono, "Preparation of complexes of liposomes with gold nanoparticles", Methods in Enzymology, 464, 131-145 (2009). DOI:10.1016/s0076_6879(09)64007_6.
• 河野健司. 「精密デリバリーを目指したリポソームの機能化」, Progress in DrugDelivery System, 18, 11-16 (2009).
• 河野健司, 「バイオ機能ナノカプセルとしてのデンドリマー」, 高分子, 58, 661-665 (2009).
• A. Harada, M. Kawamura, Y. Kimura, T. Takahashi, C. Kojima, K. Kono, "Effect of head size in head-tail type polycations on their in vitro performances as non-viral gene vectors", Macromol. Biosci., 9, 605-612 (2009). DOI:10.1002/mabi.200800314.
• 弓場英司，河野健司，「機能性リポソーム」，超分子 サイエンス＆テクノロジー，pp. 1180-1185 (2009), エヌ・ティー・エス．
• C. Kojima, S. Tsumura, A. Harada, K. Kono, "A collagen-mimic dendrimer capable of controlled release", J. Am. Chem. Soc., 131, 6052-6053 (2009). DOI:101021/ja809639c.
• C. Kojima, K. Yoshimura, A. Harada, Y. Sakanishi, K. Kono, "Synthesis and characterization of hyperbranched poly(glycidol) modified with pH- and temperature-sensitive groups", Bioconjugate Chem., 20, 1054-1057 (2009). DOI:10.1021/bc900016x.
• S. Masunaga, K. Kono, J. Nakamura, K. Tano, H. Yoshida, M. Watanabe, G. Kashino, M. Suzuki, Y. Kinashi, K. Ono, "Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal doxorubicin in vivo, referring to the effect on quiescent cells", Oncology Reports, 21, 1307-1312 (2009).
• 河野健司，弓場英司，「細胞内で機能するリポソーム」，未来材料，9 (3), 12-19 (2009).
• A. Harada, K. Nakanishi, S. Ichimura, C. Kojima, K. Kono, "Spontaneous formation of narrowly-distributed self-assembly from polyamidoamine dendron-poly(L-lysine) block copolymers through helix-coil transition of poly(L-lysine) block", J. Polym. Sci. Part A: Polym. Chem., 47, 1217-1223 (2009). DOI:10.1002/pola.23231.

2008

• 原田敦史，「バイオコンジュゲートを用いた機能性ゲルの創製」，医療用ゲルの最新技術と開発，pp. 108-114 (2008), シーエムシー．
• 原田敦史，「ナノバイオデバイスとして機能する高分子ミセル」，次世代医療のための高分子材料工学，pp. 1-10 (2008), シーエムシー．
• 河野健司，「リポソームを機能化するための高分子材料」，Drug Delivery System, 23, 644-653 (2008).
• 児島千恵，河野健司，「低侵襲医療のための光応答性ナノ粒子の作製」，放射線生物研究，43, 284-294 (2008).
• C. Kojima, Y. Toi, A. Harada, K. Kono, "Aqueous solubilization of fullerenes using poly(amidoamine) dendrimers bearing cyclodextrin and poly(ethylene glycol)", Bioconjugate Chem., 19, 2280-2284 (2008). DOI:10.1021/bc8001503.
• C. Kojima, Y. Hirano, E. Yuba, A. Harada, K. Kono, "Preparation and characterization of complexes of liposomes with gold nanoparticles", Colloids Surf. B:Biointerfaces, 66, 246-252 (2008). DOI:10.1016/j.colsurfb.2008.06.022.
• N. Sakaguchi, C. Kojima, A Harada, K. Koiwai, K. Kono, "The correlation between fusion capability and transfection activity in hybrid complexes of lipoplexes and pH-sensitive liposomes", Biomaterials, 29, 4029-4036 (2008). DOI:10.106/j.biomaterials.2008.06.006.
• N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, N. Emi, K. Kono, "Effect of transferrin as a ligand of pH-sensitive fusogenic liposome-lipoplex hybrid complexes", Bioconjugate Chem., 19, 1588-1595 (2008). DOI:10.1021/bc800126s.
• E. Yuba, C. Kojima, N. Sakaguchi, A. Harada, K. Koiwai, K. Kono, "Gene delivery to dendritic cells mediated by complexes of lipoplexes and pH-sensitive fusogenic polymer-modified liposomes", J. Control. Release, 130, 77-83 (2008). DOI:10.1016/j.jconrel.2008.05.007.
• K. Kono, T. Fukui, T. Takagishi, S. Sakurai, C. Kojima, "Preparation of poly(ethylene glycol)-modified poly(amidoamine) dendrimers with a shell of hydrophobic amino acid residues and their function as a nanocontainer", Polymer, 49, 2832-2838 (2008).
• N. Sakaguchi, C. Kojima, A. Harada, K. Kono, "Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: their ability to sensitize stable liposomes to pH", Bioconjugate Chem., 19, 1040-1048 (2008). DOI:10.1021/bc7004736.
• A. Kawamura, C. Kojima, M. Iijima, A. Harada, K. Kono, "Polyion complex micelles formed from glucose oxidase and comb-type polyelectrolyte with poly(ethylene glycol) grafts", J. Polym. Sci. Part A: Polym. Chem., 46, 3842-3852 (2008). DOI:10.1002/pola.22739.
• K. Kono, C. Kojima, N. Hayashi, E. Nishisaka, K. Kiura, S. Watarai, A. Harada, "Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin", Biomaterials, 29, 1664-1675 (2008). DOI:10.1016/j.biomaterials.2007.12.017.
• N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution", Biomaterials, 29, 1262-1272 (2008). DOI:10.1016/j.biomaterials.2007.11.016.

2007

• 河野健司，児島千恵，「温度応答性高分子を用いた温度応答性ナノキャリア」，遺伝子医学MOOK別冊，絵で見てわかるナノＤＤＳ―マテリアルから見た治療・診断・予後・予防、ヘルスケア技術の最先端―，pp. 106-112 (2007), メディカルドゥ．
• H. Horinaka, T. Matsunaka, N. Nakamura, T. Mukaiyama, S. Kawakami, K. Wada, Y. Hirano, C. Kojima, K. Kono, "Gold nanoparticle distribution monitor for drug delivery system based on optically assisted ultrasonic velocity-change imaging", Electronics Letters, 43, 1254-1255 (2007). DOI:10.1049/el:20072106.
• A. Harada, K. Johnin, A. Kawamura,K. Kono, "Preparation of temperature-responsive polymer gels physically immobilizing core-shell type bioconjugates", J. Polym. Sci. Part A: Polym. Chem., 45, 5942-5948 (2007).
• A. Kawamura, A. Harada, K. Kono, K. Kataoka, "Self-assembled nano-bioreactor from block ionomers with elevated and stabilized enzymatic function", Bioconjugate Chem., 18, 1555-1559 (2007).
• K. Kono, T. Miyoshi, Y. Haba, E. Murakami, C. Kojima, A. Harada, "Temperature sensitivity control of alkylamide-terminated poly(amidoamine) dendrimers induced by guest molecule binding", J. Am. Chem. Soc., 129, 7222-7223 (2007). DOI:10.1021/ja0711718.
• T. Takahashi, J. Hirose, C. Kojima, A. Harada, K. Kono, "Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors", Bioconjugate Chem., 18, 1163-1169 (2007). DOI:10.1021/bc070014v.
• 河野健司，児島千恵，「機能性リポソームによる遺伝子の細胞内デリバリー」，バイオプロセスハンドブック，pp. 13-20 (2007), エヌ・ティー・エス．
• T. Takahashi, C. Kojima, A. Harada, K. Kono, "Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector", Bioconjugate Chem., 18, 1349-1354 (2007). DOI:10.1021/bc060311k.
• Y. Haba, C. Kojima, A. Harada, T. Ura, H. Horinaka, K. Kono, "Preparation of poly(ethylene glycol)-modified poly(amidoamine) dendrimers encapsulating gold nanoparticles and their heat-generating ability", Langmuir, 23, 5243-5246 (2007). DOI:10.1021/la0700826.
• C. Kojima, Y. Toi, A. Harada, K. Kono, "Preparation of polyethylene glycol-attached dendrimers encapsulating photosensitizers for application to photodynamic therapy", Bioconjugate Chem., 18, 663-670 (2007). DOI:10.1021/bc060244u.
• 原田敦史，片岡一則，「ナノバイオデバイスとして機能する高分子ミセル設計」，オレオサイエンス，7, 111-118 (2007).
• A. Harada, Y. Yoshioka, A. Kawamura, C. Kojima, K. Kono, "Effect of polycarboxylate block on the amidase activity of trypsin through complexation with peg-polycarboxylate block ionomers", Macromol. Biosci., 7, 339-343 (2007). DOI:10.1002/mabi.200600199.
• S. Kakinoki, M. Kitamura, M. Yuge, M. Furuta, M. Oka, Y. Hirano, K. Kono, I. Kaetsu, "Solution property and irradiation effect of random copolypeptides composed of Ala and Pro residues", Polym. Bull., 58, 393-400 (2007). DOI:10.1007/s00289_006_0666_4.
• Y. Haba, C. Kojima, A. Harada, K. Kono, "Comparison of thermosensitive properties between poly(amidoamine) dendrimers having peripheral N-isopropylamide groups and linear polymers with the same groups", Angew. Chem. Int. Ed., 46, 234-237 (2007). DOI:10.1002/anie.200603346.

2006

• A. Harada, K. Kataoka, "Supramolecular assemblies of block copolymers in aqueous media as nanocontainers relevant to biological applications", Prog. Polym. Sci., 31, 949-982 (2006).
• 原田敦史，「内核に酵素反応場を有するコア－シェル型ナノ組織体」，酵素の活用・利用の最新技術，(2006), シーエムシー．
• A. Harada, K. Kataoka, "Stimuli responsive polyion complex assemblies", MML Series 7, Smart Nano and Microparticles, K. Kono, R. Arshady (eds.), pp. 210-229, Kentus Books, London (2006).
• K. Kono, "Stimuli responsive polymer-liposomes: formulation and in vitro evaluation", MML Series 7, Smart Nano and Microparticles, K. Kono, R. Arshady (eds.), pp. 91-123, Kentus Books, London (2006).
• 児島千恵，河野健司，「金塊よりも金ナノ微粒子－生体材料としての応用に向けて」，化学，61, 64-65 (2006).
• Y. Haba, C. Kojima, A. Harada, K. Kono, "Control of temperature-sensitive properties of poly(amidoamine) dendrimers using peripheral modification with various alkylamide groups", Macromolecules, 39, 7451-7453 (2006). DOI:10.1021/ma061019a
• 原田敦史，「遺伝子ベクターとしてのヘッド－テイル型ポリカチオンブロック共重合体の分子設計」，バイオマテリアル，24, 171-175 (2006).
• N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Enhancement of transfection activity of lipoplexes by complexation with transferrin-bearing fusogenic polymer-modified liposomes", Int. J. Pharm., 325, 186-190 (2006). DOI:10.1016/j.ijpharm.2006.06.015.
• 高橋俊成，河野健司，「刺激応答性をもつ脂質ベクター」，遺伝子医学MOOK5，ウイルスを用いない遺伝子導入法の材料，技術，方法論の新たな展開，pp. 29-36 (2006), メディカルドゥ．
• 河野健司，「機能性リポソームによる遺伝子の細胞内送達」，高分子，55, 330-333 (2006).
• Y. Tono, C. Kojima, Y. Haba, T. Takahashi, A. Harada, S. Yagi, K. Kono, "Thermosensitive properties of poly (amidoamine) dendrimers with peripheral phenylalanine residues", Langmuir, 22, 4920-4922 (2006). DOI:10.1021/la060066t.
• A. Harada, M. Kawamura, T. Matsuo, T. Takahashi, K. Kono, "Synthesis and characterization of head-tail type polycation block copolymer as non-viral gene vector", Bioconjugate Chem., 17, 3-5 (2006).

2005

• 原田敦史，「機能化高分子ナノミセル」，ソフトナノテクノロジー－バイオマテリアル革命，pp. 230-235 (2005), シーエムシー．
• 河野健司，児島千恵，「バイオメディカル機能と応用技術」，デンドリティック高分子，青井啓悟，柿本雅明　監修，pp. 319-381 (2005), エヌ・ティー・エス．
• 河野健司，「膜融合性リポソーム」，リポソーム応用の新展開，秋吉一成，辻井薫　監修，pp. 576-585 (2005), エヌ・ティー・エス．
• K. Kono, T. Murakami, T. Yoshida, Y. Haba, S. Kanaoka, T. Takagishi, S. Aoshima, "Temperature-sensitization of liposomes by use of thermosensitive block copolymers synthesized by living cationic polymerization", Bioconjugate Chem., 16, 1367-1374 (2005).
• T. Takahashi, A. Harada, N. Emi, K. Kono, "Preparation of efficient gene carriers using a polyamidoamine dendron-bearing lipid: improvement of serum resistance", Bioconjugate Chem., 16, 1160-1165 (2005).
• A. Kawamura, Y. Yoshioka, A. Harada, K. Kono, "Acceleration of enzymatic reaction of trypsin through the formation of water-soluble complexes with poly(ethylene glycol)-block-poly(α, β-aspartic acid)", Biomacromolecules, 6, 627-631 (2005).
• K. Kono, H. Akiyama, T. Takahashi, T. Takagishi, A. Harada, "Transfection activity of polyamidoamine dendrimers having hydrophobic amino acid residues in the periphery", Bioconjugate Chem., 16, 208-214 (2005).
• Y. Haba, A. Harada, T. Takagishi, K. Kono, "Synthesis of biocompatible dendrimers with a peripheral network formed by linking of polymerizable groups", Polymer, 46, 1813-1820 (2005).

• 2004年以前の業績
• 河野健司教授の業績

Copyright(C) Osaka Prefecture University Biopolymer Chemistry Group All Right Reserved