Recent Publications



  • M. Okubo, M. Miyazaki, E. Yuba, A. Harada, "Chondroitin sulfate-based pH-sensitive polymer-modified liposomes for intracellular antigen delivery and induction of cancer immunity", Bioconjugate Chemistry, accepted.
  • A. Harada, K. Nomura, E. Yuba, K. Kono, "Gene expression of aspect ratio-controlled polyplexes based on the effect of multi-arm poly(ethylene glycol)", ACS Biomaterials Science & Engineering, accepted.
  • S. Kaviarasi, E. Yuba, A. Harada, U. M. Krishnan, "Emerging paradigms in nanotechnology for imaging and treatment of cerebral ischemia", J. Control. Release, 300, 22-45 (2019). DOI: 10.1016/j.jconrel.2019.02.031. [Free until April 23]
  • S. Kaviarasi, K. S. S. Devi, P. Vinoth, V. Sridharan, E. Yuba, A. Harada, U. M. Krishnan, “Synthesis, characterization, and biomedical applications of an alkylated quercetin–gadolinium complex”, ACS Biomaterials Science & Engineering, 5, 1215-1227 (2019). DOI: 10.1021/acsbiomaterials.8b01254.
  • R. Teranishi, T. Matsuda, E. Yuba, K. Kono, A. Harada, "Sonodynamic therapeutic effects of sonosensitizers with different intracellular distribution delivered by hollow nanocapsules exhibiting cytosol specific release", Macromolecular Bioscience, in press.
  • S. Kuroyanagi, N. Shimada, S. Fujii, T. Furuta, A. Harada, K. Sakurai, A. Maruyama, “Highly ordered polypeptide with UCST phase-separation behavior”, Journal of the American Chemical Society, 141, 1261-1268 (2019). DOI: 10.1021/jacs.8b10168.













  • 河野健司,児島千恵,「温度応答性高分子を用いた温度応答性ナノキャリア」,遺伝子医学MOOK別冊,絵で見てわかるナノDDS―マテリアルから見た治療・診断・予後・予防、ヘルスケア技術の最先端―,pp. 106-112 (2007), メディカルドゥ.
  • H. Horinaka, T. Matsunaka, N. Nakamura, T. Mukaiyama, S. Kawakami, K. Wada, Y. Hirano, C. Kojima, K. Kono, "Gold nanoparticle distribution monitor for drug delivery system based on optically assisted ultrasonic velocity-change imaging", Electronics Letters, 43, 1254-1255 (2007). DOI:10.1049/el:20072106.
  • A. Harada, K. Johnin, A. Kawamura,K. Kono, "Preparation of temperature-responsive polymer gels physically immobilizing core-shell type bioconjugates", J. Polym. Sci. Part A: Polym. Chem., 45, 5942-5948 (2007).
  • A. Kawamura, A. Harada, K. Kono, K. Kataoka, "Self-assembled nano-bioreactor from block ionomers with elevated and stabilized enzymatic function", Bioconjugate Chem., 18, 1555-1559 (2007).
  • K. Kono, T. Miyoshi, Y. Haba, E. Murakami, C. Kojima, A. Harada, "Temperature sensitivity control of alkylamide-terminated poly(amidoamine) dendrimers induced by guest molecule binding", J. Am. Chem. Soc., 129, 7222-7223 (2007). DOI:10.1021/ja0711718.
  • T. Takahashi, J. Hirose, C. Kojima, A. Harada, K. Kono, "Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors", Bioconjugate Chem., 18, 1163-1169 (2007). DOI:10.1021/bc070014v.
  • 河野健司,児島千恵,「機能性リポソームによる遺伝子の細胞内デリバリー」,バイオプロセスハンドブック,pp. 13-20 (2007), エヌ・ティー・エス.
  • T. Takahashi, C. Kojima, A. Harada, K. Kono, "Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector", Bioconjugate Chem., 18, 1349-1354 (2007). DOI:10.1021/bc060311k.
  • Y. Haba, C. Kojima, A. Harada, T. Ura, H. Horinaka, K. Kono, "Preparation of poly(ethylene glycol)-modified poly(amidoamine) dendrimers encapsulating gold nanoparticles and their heat-generating ability", Langmuir, 23, 5243-5246 (2007). DOI:10.1021/la0700826.
  • C. Kojima, Y. Toi, A. Harada, K. Kono, "Preparation of polyethylene glycol-attached dendrimers encapsulating photosensitizers for application to photodynamic therapy", Bioconjugate Chem., 18, 663-670 (2007). DOI:10.1021/bc060244u.
  • 原田敦史,片岡一則,「ナノバイオデバイスとして機能する高分子ミセル設計」,オレオサイエンス7, 111-118 (2007).
  • A. Harada, Y. Yoshioka, A. Kawamura, C. Kojima, K. Kono, "Effect of polycarboxylate block on the amidase activity of trypsin through complexation with peg-polycarboxylate block ionomers", Macromol. Biosci., 7, 339-343 (2007). DOI:10.1002/mabi.200600199.
  • S. Kakinoki, M. Kitamura, M. Yuge, M. Furuta, M. Oka, Y. Hirano, K. Kono, I. Kaetsu, "Solution property and irradiation effect of random copolypeptides composed of Ala and Pro residues", Polym. Bull., 58, 393-400 (2007). DOI:10.1007/s00289_006_0666_4.
  • Y. Haba, C. Kojima, A. Harada, K. Kono, "Comparison of thermosensitive properties between poly(amidoamine) dendrimers having peripheral N-isopropylamide groups and linear polymers with the same groups", Angew. Chem. Int. Ed., 46, 234-237 (2007). DOI:10.1002/anie.200603346.


  • A. Harada, K. Kataoka, "Supramolecular assemblies of block copolymers in aqueous media as nanocontainers relevant to biological applications", Prog. Polym. Sci., 31, 949-982 (2006).
  • 原田敦史,「内核に酵素反応場を有するコア-シェル型ナノ組織体」,酵素の活用・利用の最新技術,(2006), シーエムシー.
  • A. Harada, K. Kataoka, "Stimuli responsive polyion complex assemblies", MML Series 7, Smart Nano and Microparticles, K. Kono, R. Arshady (eds.), pp. 210-229, Kentus Books, London (2006).
  • K. Kono, "Stimuli responsive polymer-liposomes: formulation and in vitro evaluation", MML Series 7, Smart Nano and Microparticles, K. Kono, R. Arshady (eds.), pp. 91-123, Kentus Books, London (2006).
  • 児島千恵,河野健司,「金塊よりも金ナノ微粒子-生体材料としての応用に向けて」,化学61, 64-65 (2006).
  • Y. Haba, C. Kojima, A. Harada, K. Kono, "Control of temperature-sensitive properties of poly(amidoamine) dendrimers using peripheral modification with various alkylamide groups", Macromolecules, 39, 7451-7453 (2006). DOI:10.1021/ma061019a
  • 原田敦史,「遺伝子ベクターとしてのヘッド-テイル型ポリカチオンブロック共重合体の分子設計」,バイオマテリアル24, 171-175 (2006).
  • N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Enhancement of transfection activity of lipoplexes by complexation with transferrin-bearing fusogenic polymer-modified liposomes", Int. J. Pharm., 325, 186-190 (2006). DOI:10.1016/j.ijpharm.2006.06.015.
  • 高橋俊成,河野健司,「刺激応答性をもつ脂質ベクター」,遺伝子医学MOOK5,ウイルスを用いない遺伝子導入法の材料,技術,方法論の新たな展開,pp. 29-36 (2006), メディカルドゥ.
  • 河野健司,「機能性リポソームによる遺伝子の細胞内送達」,高分子55, 330-333 (2006).
  • Y. Tono, C. Kojima, Y. Haba, T. Takahashi, A. Harada, S. Yagi, K. Kono, "Thermosensitive properties of poly (amidoamine) dendrimers with peripheral phenylalanine residues", Langmuir, 22, 4920-4922 (2006). DOI:10.1021/la060066t.
  • A. Harada, M. Kawamura, T. Matsuo, T. Takahashi, K. Kono, "Synthesis and characterization of head-tail type polycation block copolymer as non-viral gene vector", Bioconjugate Chem., 17, 3-5 (2006).


  • 原田敦史,「機能化高分子ナノミセル」,ソフトナノテクノロジー-バイオマテリアル革命,pp. 230-235 (2005), シーエムシー.
  • 河野健司,児島千恵,「バイオメディカル機能と応用技術」,デンドリティック高分子,青井啓悟,柿本雅明 監修,pp. 319-381 (2005), エヌ・ティー・エス.
  • 河野健司,「膜融合性リポソーム」,リポソーム応用の新展開,秋吉一成,辻井薫 監修,pp. 576-585 (2005), エヌ・ティー・エス.
  • K. Kono, T. Murakami, T. Yoshida, Y. Haba, S. Kanaoka, T. Takagishi, S. Aoshima, "Temperature-sensitization of liposomes by use of thermosensitive block copolymers synthesized by living cationic polymerization", Bioconjugate Chem., 16, 1367-1374 (2005).
  • T. Takahashi, A. Harada, N. Emi, K. Kono, "Preparation of efficient gene carriers using a polyamidoamine dendron-bearing lipid: improvement of serum resistance", Bioconjugate Chem., 16, 1160-1165 (2005).
  • A. Kawamura, Y. Yoshioka, A. Harada, K. Kono, "Acceleration of enzymatic reaction of trypsin through the formation of water-soluble complexes with poly(ethylene glycol)-block-poly(α, β-aspartic acid)", Biomacromolecules, 6, 627-631 (2005).
  • K. Kono, H. Akiyama, T. Takahashi, T. Takagishi, A. Harada, "Transfection activity of polyamidoamine dendrimers having hydrophobic amino acid residues in the periphery", Bioconjugate Chem., 16, 208-214 (2005).
  • Y. Haba, A. Harada, T. Takagishi, K. Kono, "Synthesis of biocompatible dendrimers with a peripheral network formed by linking of polymerizable groups", Polymer, 46, 1813-1820 (2005).