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11) C. Kojima, "Section I: Chapter 5: Multifunctional dendrimers as cancer nanomedicines: Peptide-based targeting", Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology (Ed. D. Chitkara, A. Mittal, R. I. Mahato), CRC Press (2018).

10) C. Kojima, "Chapter 12: Design of biomimetic interfaces at the dendrimer periphery and their applications", Stimuli-Responsive Interfaces Fabrication and Application (Ed. T. Kawai, M. Hashizume), Springer, 209-228 (2016).

9)  C. Kojima, "Preclinical studies of dendrimer prodrugs", Expert Opin. Drug Metab. Toxicol., 11, 1303-1315 (2015).

8)  U. H. Sk, C. Kojima, "Dendrimers for drug delivery of anticancer drugs", Frontiers in Clinical Drug Research - Anti-Cancer Agents (Ed. Atta-ur-Rahman), Vol.2 Bentham science publishers, 3-25 (2015).

7) U. H. Sk, C. Kojima, "Dendrimers for theranostic applications", Biomolecular Concepts, 6, 205-217 (2015).

6) T. Iida, S.Ito, S.Tokonami, C. Kojima, "Chapter 5: Nano-optomechanics by tailored light fields under fluctuations", Progress in Nanophotonics 3, Nano-Optics and Nanophotonics (Ed. M. Ohtsu and T. Yatsui), Springer, 167-202 (2015).

5) C. Kojima, "Chapter 4: smart dendrimers", Smart Materials for Drug Delivery (Ed. C. Alvarez-Lorenzo and A. Concheiro), Royal society of chemistry, 94-114 (2013).

4) C. Kojima, "Dendrimers", Encyclopedia of Polymer Science and Technology, Wiley, online publication (2012).

3) C. Kojima, "Chapter 8: Design of stimuli-responsive dendrimers for biomedical purposes", Dendrimer-Based Drug Delivery Systems: From Theory to Practice (Ed. Y. Cheng), Wiley, 307-327 (2012).(査読なし)

2) C. Kojima, "Design of stimuli-responsive dendrimers", Expert Opin. Drug Deliv., 7, 307-319 (2010).

1) C. Kojima, Y. Hirano, K. Kono, "Preparation of complexes of liposomes with gold nanoparticles", Methods in Enzymology, 464, 131-145 (2009).(査読なし)




101)  C. Kojima, H. Xia, Y. Yamamoto, H. Shiigi, "A naked-eye colorimetric pH and temperature sensor based on gold nanoparticle-loaded stimuli-sensitive dendrimers", ChemNanoMat, accepted.

100)  H. Shiba, M. Nishio, M. Sawada, M. Tamaki, M. Michigami, S. Nakai, I. Nakase, I. Fujii, A. Matsumoto, C. Kojima, "Carboxy-terminal dendrimers with phenylalanine for pH-sensitive delivery system into immune cells including T cells", J. Mater. Chem. B, in press.

99)  C. Jing, K. Osada, C. Kojima, Y. Suzuki, A. Matsumoto, "RAFT polymerization of 2-(tert-Butoxycarbonyloxy)ethyl methacrylate and transformation to functional polymers via deprotection and the subsequent polymer reactions", Macromol. Chem. Phys., 223, 227001 (2022).


98) C. Kojima, A. Kanetsuki, Y. Nakajima, T. Kawano, K. Takatsuka, S. Tanaka, Y. Haraguchi, K. Matsuura, T. Shimizu, "Cell detachment from monolayer- and bilayer-types gold nanoparticle-containing collagen coatings by visible laser irradiation for the application to cell sorting", Polym. J., 53, 1485-1491 (2021).

97) C. Kojima, T. Hirose, R. Katayama, A. Matsumoto, "Solubilization of paclitaxel by self-assembled amphiphilic phospholipid-mimetic polymers with different structures", Polymers, 13, 2805 (2021).

96) C. Kojima, T. Koda, T. Nariai, J. Ichihara, K. Sugiura, A. Matsumoto, "Application of zwitterionic polymer hydrogels to optical tissue clearing for 3D fluorescence imaging", Macromol. Biosci., 21, 2100170 (2021). Selected as the cover image of Volume 21, Issue 9, published on September 18, 2021.

95) A. Tsujimoto, H. Uehara, H. Yoshida, M. Nishio, K. Furuta, T. Inui, A. Matsumoto, S. Morita, M. Tanaka, C. Kojima, "Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density", Mater. Sci. Eng. C, 126, 112159 (2021).

94) K. Nagai, T. Sato, C. Kojima, "Design of a dendrimer with a matrix metalloproteinase-responsive fluorescence probe and a tumor-homing peptide for metastatic tumor cell imaging in the lymph node", Bioorg. Med. Chem. Lett., 33, 127726 (2021).

93) C. Kojima, Y. Nakajima, T. Kawano, K. Takatsuka, "Preparation of a visible light-responsive gold nanoparticle-containing collagen gel microarray for in situ cell separation", Res. Chem. Intermediates, 47, 51-60 (2021).


92) T. L. Nguyen, R. Katayama, C. Kojima, A. Matsumoto, K. Ishihara, S. Yusa, "Singlet oxygen generation by sonication using a water-soluble fullerene (C60) complex: a potential application for sonodynamic therapy", Polymer J.,52, 1387-1394 (2020).

91) C. Kojima, R. Katayama, T. L. Nguyen, Y. Oki, A. Tsujimoto, S. Yusa, K. Shiraishi, A. Matsumoto, "Different antifouling effects of random and block copolymers comprising 2-methacryloyloxyethyl phosphorylcholine and dodecyl methacrylate", Eur. Polymer J., 136, 109932 (2020).

90) Y. Nishimoto, M. Nishio, S. Nagashima, K. Nakajima, T. Ohira, S. Nakai, I. Nakase, K. Higashikawa, Y. Kuge, A. Matsumoto, M. Ogawa, C. Kojima, "Association of hydrophobic carboxyl-terminal dendrimers with lymph node-resident lymphocytes", Polymers, 12, 1474 (2020).

89) R. Katayama, N. Tanaka, Y. Takagi, K. Shiraishi, Y. Tanaka, A. Matsumoto, C. Kojima, "Characterization of the hydration process of phospholipid-mimetic polymers using the air injection-mediated liquid exclusion methods", Langmuir, 36, 5626-5632 (2020).

88) M. Tamaki, C. Kojima, "pH-Switchable LCST/UCST-type thermosensitive behaviors of phenylalanine-modified zwitterionic dendrimers", RSC Advances, 10, 10452-10460 (2020).

87) Y. Nishimoto, S. Nagashima, K. Nakajima, T. Ohira, T. Sato, T. Izawa, J. Yamate, K. Higashikawa, Y. Kuge, M. Ogawa, C. Kojima, "Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting", Int. J. Pharm., 576, 119021 (2020).

86) C. Kojima, M. Nishio, Y. Nakajima, T. Kawano, K. Takatsuka, A. Matsumoto, "Rapid photoinduced single cell detachment from gold nanoparticle-embedded collagen gels with low denaturation temperature", Polymers, 12, 213 (2020).


85) T. Koda, S. Dohi, H. Tachi, Y. Suzuki, C. Kojima, A. Matsumoto, "One-shot preparation of polyacrylamide/poly(sodium styrenesulfonate) double network hydrogels for rapid optical tissue clearing", ACS Omega, 4, 21083-21090 (2019).

84) C. Kojima, Y. Narita, Y. Nakajima, N. Morimoto, T. Yoshikawa, N. Takahashi, A. Handa, T. Waku, N. Tanaka, "Modulation of cell adhesion and differentiation on collagen gels by the addition of the ovalbumin secretory signal peptide", ACS Biomater. Sci. Eng., 5, 5698-5704 (2019).

83) C. Kojima, Y. Ono, T. Koda, A. Matsumoto, "Rapid optical tissue clearing using various anionic polymer hydrogels", Mater. Today Commun., 21, 100611 (2019).

82) Y. Ono, I. Nakase, A. Matsumoto, C. Kojima, "Rapid optical tissue clearing using poly(acrylamide-co-styrenesulfonate) hydrogels for three-dimensional imaging", J. Biomed. Mater. Res. B, 107, 2297-2304 (2019).

81) R. Katayama, M. Ikeda, K. Shiraishi, A. Matsumoto, C. Kojima, "Formation of hydrophobic domains on the poly(MPC-co-dodecyl methacrylate)-coated surface recognized by macrophage-like cells", Langmuir, 35, 12229-12235 (2019).

80) Y. Nishimoto, S. Nagashima, C. Kojima, "Matrix metalloproteinase-2-activatable peptide probe-modified dendrimer for tumor cell detection", Peptide Science 2018, 98-99 (2019). (Proceeding)

79) C. Kojima, K. Watanabe, H. Murata, Y. Nishio, R. Makiura, K. Matsunaga, A. Nakahira, "Controlled release of DNA from zinc and magnesium ion-doped hydroxyapatites", Res. Chem. Intermediates, 45, 23-32 (2019).


78) M. Tamaki, D. Fukushima, C. Kojima, "Dual pH-sensitive and UCST-type thermosensitive dendrimers: phenylalanine-modified polyamidoamine dendrimers with carboxyl termini", RSC Advances, 8, 28147-28151 (2018).

77) Y. Nakajima, T. Kawano, Y. Taki, C. Kojima, "Visible light-responsive cell scaffolds with bilayer structures for single cell separation", Res. Chem. Intermediates, 44, 4745-4754 (2018).

76) C. Kojima, K. Saito, E. Kondo, "Design of peptide-dendrimer conjugates with tumor homing and antitumor effects", Res. Chem. Intermediates, 44, 4685-4695 (2018).


75) T. Harashima, C. Kojima, S. Fujii, M. Kiguchi, and T. Nishino, "Single-molecule conductance of DNA gated and ungated by DNA-binding molecules", Chem. Commun., 53,10378-10381 (2017).

74) C. Kojima, Y. Nakajima, N. Oeda, T. Kawano, Y. Taki, "Visible laser-induced in situ cell detachment from gold nanoparticle-embedded collagen gel", Macromol. Biosci., 17, 1600341 (2017).

73) C. Kojima, Y. Narita, T. Waku, N. Morimoto, D. Togawa, N. Takahashi, A. Handa, N. Tanaka, "Ovalbumin secretory signal peptide-containing collagen gel as a cell scaffold", Chem. Lett., 46, 395-397 (2017).


72) C. Kojima, E. Fusaoka-Nishioka, T. Imai, A. Nakahira, H. Onodera, "Dendrigraft polylysine coated-poly(glycolic acid) fibrous scaffolds for hippocampal neurons", J. Biomed. Mater. Res. A, 104, 2744-2750 (2016).

71) K. Saito, H. Iioka, C. Kojima, M. Ogawa, E. Kondo, "Peptide-based tumor inhibitor encoding mitochondrial p14ARF is highly efficacious to diverse tumors", Cancer Sci., 107, 1290-1301 (2016).

70) C. Kojima, D. Fukushima, "Applications of gold nanoparticle-loaded thermosensitive elastin-mimetic dendrimer to photothermal therapy", J. Photopolym. Sci. Technol., 29, 519-523 (2016).


69) C. Kojima, U. H. Sk, D. Fukushima, K. Irie, N. Akazawa, M. Umeda, T. Niidome, "Effect of main chain conformation on thermosensitivity in elastin-like peptide-grafted polylysine", RSC Advances, 5, 104900-104906 (2015).

68) Y. Niki, M. Ogawa, R. Makiura, Y. Magata, C. Kojima, "Optimization of dendrimer structure for sentinel lymph node imaging: Effects of generation and terminal group", Nanomedicine, 11, 2119-2127 (2015).

67) C. Kojima, R. Kameyama, M. Yamada, M. Ichikawa, T. Waku, A. Handa, N. Tanaka, "Ovalbumin delivery by guanidine-terminated dendrimers bearing an amyloid-promoting peptide via nanoparticle formulation", Bioconjugate Chem., 26, 1804-1810 (2015).

66) D. Fukushima, U. H. Sk, Y. Sakamoto, I. Nakase, C. Kojima, "Dual stimuli-sensitive dendrimers: photothermogenic gold nanoparticle-loaded thermo-responsive elastin-mimetic dendrimers", Colloid Surf. B-Biointerfaces, 132, 155-160 (2015).


65) C. Kojima, Y. Niki, M. Ogawa, Y. Magata, "Prolonged local retention of subcutaneously injected polymers monitored by noninvasive SPECT imaging", Int. J. Pharm., 476, 164-168 (2014).

64) C. Kojima, N. Oeda, S. Ito, H. Miyasaka, T. Iida, "Photothermogenic properties of different sized gold nanoparticles for application in photothermal therapy", Chem. Lett., 43, 975-976 (2014).

63) C. Kojima, K. Irie, T. Tada, N. Tanaka, "Temperature-sensitive elastin-mimetic dendrimers: effect of peptide length and dendrimer generation to temperature sensitivity", Biopolymers, 101, 603-612 (2014).

62) K. Shitara, H. Murata, K. Watanabe, C. Kojima, Y. Sumida, A. Nakamura, A. Nakahira, I. Tanaka, K. Matsunaga, "Cytotoxicity of stoichiometric hydroxyapatites with different crystallite sizes", J. Asian Ceram. Soc., 2, 64-67 (2014).


61) C. Kojima, K. Watanabe, T. Nagayasu, Y. Nishio, R. Makiura, A. Nakahira, "Preparation of hydroxyapatite-decorated poly(lactide-co-glycolide) microspheres for paclitaxel delivery", J. Nanoparticle Res., 15, 2098 (2013).

60) C. Kojima, K. Irie, "Synthesis of temperature-dependent elastin-like peptide-modified dendrimer for drug delivery", Biopolymers:Peptide Sci., 100, 714-721 (2013).

59)  C. Kojima, E. Nishisaka, T. Suehiro, K. Watanabe, A. Harada, T. Goto, Y. Magata, K. Kono, "The synthesis and evaluation of polymer prodrug/collagen hybrid gels for delivery into metastatic cancer cells", Nanomedicine, 9, 767-775 (2013).

58)  C. Kojima, H. Kawabata, A. Harada, H. Horinaka, K. Kono, "Design of a novel drug carrier with photo-responsive properties: drug-encapsulated and alkanethiol-modified gold nanoparticle-loaded PEGylated dendrimer", Chem. Lett., 42, 612-614 (2013).

57)  K. Watanabe, Y. Nishio, R. Makiura, A. Nakahira, C. Kojima, "Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells", Int. J. Pharm., 446, 81-86 (2013).

56)  C. Kojima, H. Fukada, T. Inui, "Synthesis and binding properties of peptidomimetics based on a dendritic polymer", Polymer J., 45, 339-345 (2013).

55)  C. Kojima, T. Suehiro, K. Watanabe, M. Ogawa, A. Fukuhara, E. Nishisaka, A. Harada, K. Kono, T. Inui, Y. Magata, "Doxorubicin-conjugated dendrimer/collagen hybrid gels for metastasis-associated drug delivery system", Acta Biomaterialia, 9, 5673-5680 (2013).


54)  S. Yagi, N. Oeda, C. Kojima, "Electroless growth of size-controlled gold nanoparticles using hydroquinone", J. Electrochem. Soc., 159, H668-H673 (2012).

53)  E. Yuba, Y. Nakajima, S. Iwashita, C. Kojima, A. Harada, K. Kono, "Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids", J. Control. Release, 160, 552-560 (2012).

52) K. Kono, R. Ikeda, K. Tsukamoto, E. Yuba, C. Kojima, A. Harada, "Polyamidoamine dendron-bearing lipids as a non-viral vector: influence of dendron generation", Bioconjugate Chem., 23, 871-879 (2012).

51) C. Kojima, K. Watanabe, "Adsorption and desorption of bioactive proteins on hydroxyapatite for protein delivery systems", J. Drug Deliv., 2012, 932461 (2012).

50) C. Kojima, S.-H. Cho, E. Higuchi, "Gold nanoparticle-loaded PEGylated dendrimers for theragnosis", Res. Chem. Intermediates, 38, 1279-1289 (2012).


49) C. Kojima, B. Turkbey, M. Ogawa, M. Bernardo, C. A. S. Regino, L. H. Bryant, Jr., P. L. Choyke, K. Kono, H. Kobayashi, "Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics", Nanomedicine, 7, 1001-1008 (2011).

48) C. Kojima, T. Suehiro, "Improvement of temperature-responsive drug release from collagen-mimic dendrimers", Chem. Lett., 40, 1249-1251 (2011).

47) C. Kojima, Y. Watanabe, H. Hattori, T. Iida, "Design of photosensitive gold nanoparticles for biomedical applications based on self-consistent optical response theory", J. Phys. Chem. C, 115, 19091-19095 (2011).

46) C. Kojima, T. Suehiro, T. Tada, Y. Sakamoto, T. Waku, N. Tanaka, "Preparation of heat-induced artificial collagen gels based on collagen-mimetic dendrimers", Soft Matter, 7, 8991-8997 (2011).

45) K. Kono, E. Murakami, Y. Hiranaka, E. Yuba, C. Kojima, A. Harada, K. Sakurai, "Thermosensitive molecular assemblies from poly(amidoamine) dendron-based lipids", Angew. Chem. Int. Ed., 50(28), 6332-6336 (2011).

44) A. Harada, T. Kato, A. Kawamura, C. Kojima, K. Kono, "Effect of enzyme modification by well defined multi-armed poly(ethylene glycol) synthesized using polyamidoamine dendron", J. Biomaterials Science: Polymer Edition, 22, 1551-1591 (2011).

43) T. Suehiro, T. Tada, T. Waku, N. Tanaka, C. Hongo, S. Yamamoto, A. Nakahira, C. Kojima, "Temperature-dependent higher order structures of the (Pro-Pro-Gly)10-modified dendrimer", Biopolymers, 95, 270-277 (2011).

42) K. Kono, S. Nakashima, D. Kokuryo, I. Aoki, H. Shimomoto, S. Aoshima, K. Maruyama, E. Yuba, C. Kojima, A. Harada, Y. Ishizaka, "Multifunctional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy", Biomaterials, 32, 1387-1395 (2011).


41) C. Kojima, Y. Umeda, A. Harada, K. Kono, "Preparation of near-infrared light absorbing gold nanoparticles using polyethylene glycol-attached dendrimers", Colloids and Surf. B: Biointerfaces, 81, 648-651 (2010).

40) C. Kojima, K. Yoshimura, A. Harada, Y. Sakanishi, K. Kono, "Temperature-sensitive hyperbranched poly(glycidol)s with oligo(ethylene glycol) monoethers", J. Polym. Sci. Part A: Polym. Chem., 48, 4047-4054 (2010).

39) Y. Umeda, C. Kojima, A. Harada, H. Horinaka, K. Kono, "PEG-attached PAMAM dendrimers encapsulating gold nanoparticles: growing gold nanoparticles in the dendrimers for improvement of their photothermal properties", Bioconjugate Chem., 21, 1559-1564 (2010).
>>> Highlighted in "nanotechweb"

38) K. Kono, T. Ozawa, T. Yoshida, F. Ozaki, Y. Ishizaka, K. Maruyama, C. Kojima, A. Harada, S. Aoshima, "Highly temperature-sensitive liposomes based on a thermosensitive block copolymer for tumor-specific chemotherapy", Biomaterials, 31, 7096-7105 (2010).

37) C. Kojima, Y. Umeda, M. Ogawa, A. Harada, Y. Magata, K. Kono, "X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticle in PEGylated dendrimer", Nanotechnology, 21, 245104 (2010).
>>> Highlighted in "nanotechweb"

36) A. Harada, Y. Kimura, C. Kojima, K. Kono , "Effective tolerance to serum proteins of head-tail type polycation vectors by PEGylation at the periphery of the head block", Biomacromolecules, 11, 1036-1042 (2010).

35) T. Suehiro, C. Kojima, S. Tsumura, A. Harada, K. Kono, "Higher order structure of short collagen model peptides attached to dendrimers and linear polymers", Biopolymers, 93, 640-648 (2010).

34) A. Harada, A. Yuzawa, T. Kato, C. Kojima, K. Kono, "Effect of pH and generation of dendron on single-step synthesis of gold nanoparticles using PEGylated polyamidoamine dendron in aqueous medium", J. Polym. Sci. Part A: Polym. Chem., 48, 1391-1398 (2010).

33) E. Yuba, C. Kojima, A. Harada, Tana, S. Watarai, K. Kono, "pH-Sensitive fusogenic polymer-modified liposomes as a carrier of antigenic proteins for activation of cellular immunity", Biomaterials, 31, 943-951 (2010).

32) C. Kojima, C. Regino, Y. Umeda, H. Kobayashi, K. Kono, "Influence of dendrimer generation and polyethylene glycol length on the biodistribution of pegylated dendrimers", Int. J. Pharm., 383, 293-296 (2010).


31) T. Takahashi, E. Yuba, C. Kojima, A. Harada, K. Kono, "Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors", Res. Chem. Intermediates, 35, 1005-1014 (2009).

30) K. Miura, J. M. Nam, C. Kojima, N. Mochizuki, H. Sabe, "EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts", Mol. Biol. Cell, 20, 1949-1959 (2009).

29) C. Kojima, S. Tsumura, A. Harada, K. Kono, "A collagen-mimic dendrimer capable of controlled release", J. Am. Chem. Soc., 131, 6052-6053 (2009).

28) C. Kojima, K. Yoshimura, A. Harada, Y. Sakanishi, K. Kono, "Synthesis and characterization of hyperbranched poly(glycidol) modified with pH- and temperature-sensitive groups", Bioconjugate Chem., 20, 1054-1057 (2009).

27) A. Harada, M. Kawamura, Y. Kimura, T. Takahashi, C. Kojima, K. Kono, "Effect of head size in head-tail type polycations on their in vitro performances as non-viral gene vectors", Macromol. Biosci., 9, 605-612 (2009).

26) A. Harada, K. Nakanishi, S. Ichimura, C. Kojima, K. Kono, "Spontaneous formation of narrowly-distributed self-assembly from polyamidoamine dendron-poly(L-lysine) block copolymers through helix-coil transition of poly(L-lysine) block", J. Polym. Sci. Part A: Polym. Chem., 47, 1217-1223 (2009).


25) C. Kojima, Y. Toi, A. Harada, K. Kono, "Aqueous solubilization of fullerenes using poly(amidoamine) dendrimers bearing cyclodextrin and poly(ethylene glycol)", Bioconjugate Chem., 19, 2280-2284 (2008).

24) C. Kojima, Y. Hirano, E. Yuba, A. Harada, K. Kono, "Preparation and characterization of complexes of liposomes with gold nanoparticles", Colloid Surf. B-Biointerfaces, 66, 246-252 (2008).
(2008年10月〜12月間 Most downloaded article, #1)

23) N. Sakaguchi, C. Kojima, A Harada, K. Koiwai, K. Kono, "The correlation between fusion capability and transfection activity in hybrid complexes of lipoplexes and pH-sensitive liposomes", Biomaterials, 29, 4029-4036 (2008).

22) N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, N. Emi, K. Kono, "Effect of transferrin as a ligand of pH-sensitive fusogenic liposome-lipoplex hybrid complexes", Bioconjugate Chem., 19, 1588-1595 (2008).

21) E. Yuba, C. Kojima, N. Sakaguchi, A. Harada, K. Koiwai, K. Kono, "Gene delivery to dendritic cells mediated by complexes of lipoplexes and pH-sensitive fusogenic polymer-modified liposomes", J. Control. Release, 130, 77-83 (2008).

20) K. Kono, T. Fukui, T. Takagishi, S. Sakurai, C. Kojima, "Preparation of poly(ethylene glycol)-modified poly(amidoamine) dendrimers with a shell of hydrophobic amino acid residues and their function as a nanocontainer", Polymer, 49, 2832-2838 (2008).

19) N. Sakaguchi, C. Kojima, A. Harada, K. Kono, "Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: their ability to sensitize stable liposomes to pH", Bioconjugate Chem., 19, 1040-1048 (2008).

18) A. Kawamura, C. Kojima, M. Iijima, A. Harada, K. Kono, "Polyion complex micelles formed from glucose oxidase and comb-type polyelectrolyte with poly(ethylene glycol) grafts", J. Polym. Sci. Part A: Polym. Chem., 46, 3842-3852 (2008).

17) K. Kono, C. Kojima, N. Hayashi, E. Nishisaka, K. Kiura, S. Watarai, A. Harada, "Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin", Biomaterials, 29, 1664-1675 (2008).

16) N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution", Biomaterials, 29, 1262-1272 (2008).


15) H. Horinaka, T. Matsunaka, N. Nakamura, T. Mukaiyama, S. Kawakami, K. Wada, Y. Hirano, C. Kojima, K. Kono, "Gold nanoparticle distribution monitor for drug delivery system based on optically assisted ultrasonic velocity-change imaging", Electron. Lett., 43, 1254-1255 (2007).

14) K. Kono, T. Miyoshi, Y. Haba, E. Murakami, C. Kojima, A. Harada, "Temperature sensitivity control of alkylamide-terminated poly(amidoamine) dendrimers induced by guest molecule binding", J. Am. Chem. Soc., 129, 7222-7223 (2007).

13) T. Takahashi, J. Hirose, C. Kojima, A. Harada, K. Kono, "Synthesis of poly(amidoamine) dendron-bearing lipids with poly(ethylene glycol) grafts and their use for stabilization of nonviral gene vectors", Bioconjugate Chem., 18, 1163-1169 (2007).

12) T. Takahashi, C. Kojima, A. Harada, K. Kono, "Alkyl chain moieties of polyamidoamine dendron-bearing lipids influence their function as a nonviral gene vector", Bioconjugate Chem., 18, 1349-1354 (2007).

11) Y. Haba, C. Kojima, A. Harada, T. Ura, H. Horinaka, K. Kono, "Preparation of poly(ethylene glycol)-modified poly(amidoamine) dendrimers encapsulating gold nanoparticles and their heat-generating ability", Langmuir, 23, 5243-5246 (2007).

10) C. Kojima, Y. Toi, A. Harada, K. Kono, "Preparation of polyethylene glycol-attached dendrimers encapsulating photosensitizers for application to photodynamic therapy", Bioconjugate Chem., 18, 663-670 (2007).

9) A. Harada, Y. Yoshioka, A. Kawamura, C. Kojima, K. Kono, "Effect of polycarboxylate block on the amidase activity of trypsin through complexation with peg-polycarboxylate block ionomers", Macromol. Biosci., 7, 339-343 (2007).

8) Y. Haba, C. Kojima, A. Harada, K. Kono, "Comparison of thermosensitive properties of poly(amidoamine) dendrimers with peripheral N-isopropylamide groups and linear polymers with the same groups", Angew. Chem. Int. Ed., 46, 234-237 (2007).


7) Y. Haba, C. Kojima, A. Harada, K. Kono, "Control of temperature-sensitive properties of poly(amidoamine) dendrimers using peripheral modification with various alkylamide groups", Macromolecules, 39, 7451-7453 (2006).

6) N. Sakaguchi, C. Kojima, A. Harada, K. Koiwai, K. Shimizu, N. Emi, K. Kono, "Enhancement of transfection activity of lipoplexes by complexation with transferrin-bearing fusogenic polymer-modified liposomes", Int. J. Pharm., 325, 186-190 (2006).

5) Y. Tono, C. Kojima, Y. Haba, T. Takahashi, A. Harada, S. Yagi, K. Kono, "Thermosensitive properties of poly(amidoamine) dendrimers with peripheral phenylalanine residues", Langmuir, 22, 4920-4922 (2006).

2000 〜 2005

4) C. Kojima, A. Hashimoto, I. Yabuta, M. Hirose, S. Hashimoto, Y. Kanaho, H. Sumimoto, T. Ikegami, H. Sabe, " Regulation of Bin1 SH3 domain binding by phosphoinositides ", EMBO J., 23, 4413-4422 (2004).

3) S. Hashimoto, A. Hashimoto, A. Yamada, C. Kojima, Y. Yamamoto, T. Tsutsumi, M. Higashi, A. Mizoguchi, H. Sabe, " A Novel mode of action of an ArfGAP, AMAP2/PAG3/Papa, in Arf6 Function ", J. Biol. Chem., 279, 37677-37684 (2004).

2) C. Kojima, Y. Haba, T. Fukui, K. Kono, T. Takagishi, "Design of biocompatible dendrimers with environment-sensitivity", Macromolecules, 36, 2183-2186 (2003).

1) C. Kojima, K. Kono, K. Maruyama, T. Takagishi, "Synthesis of polyamidoamine dendrimers having polyethylene glycol grafts and their ability to encapsulate anticancer drugs", Bioconjugate Chem., 11, 910-917 (2000).(2015年、25th anniversary collectionに選出。被引用回数400回以上)