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Creation of next generation biomaterials from interdisciplinary study

The continuing development of medical technology is extremely important. In our laboratory, we are researching next generation functional biomaterials to aid the development of innovative medical technology. I have a background in molecular biology and polymer science. Based on this research background, we are developing next generation of functional biomaterials using two approaches (Figure 1). This type of research requires the fusion of different fields, so we promote and implement joint research with laboratories from various disciplines at Osaka Prefecture University, research institutes of biology, and medical schools.

Creation of next generation biomaterials from interdisciplinary study

Figure 1. Creation of next generation biomaterials from interdisciplinary study.

  

  1. Approach to polymer materials science

The cell is made up of 70% water and 30% other compounds. Protein, which constitutes 18% of the cell, performs a variety of functions. Protein is a biopolymer, with a higher-order structure folded into a regular configuration. The molecular weight and structure of man-made synthetic polymers, however, are generally difficult to control. In the molecular design of bio-functional materials, polymers may be useful in controlling structure. The dendrimer is a synthetic polymer in which the molecular weight and structure can be controlled. A lot of reactive functional groups on the surface and the internal space sufficient to hold the low molecular weight of the dendrimer make it an attractive research tool (Figure 2). We aim to utilize these beneficial characteristics of the dendrimer to develop functional biomaterials.

Structure of dendrimers

Figure 2. Structure of dendrimers.

-->> see Dendrimer, Stimuli-sensitive polymers.

  

  2. Approach from molecular biology

Cancer, heart disease and cerebrovascular disease are three major causes of death in Japan. Rates of cancer are increasing every year and it is estimated that one in twenty people will suffer from cancer in 2015, when 'baby boomers' will have reached the most vulnerable age for cancer. Research into developing medical materials for cancer treatment is therefore very important. Many studies have examined the specific properties and molecular mechanisms of cancer. We are attempting to produce functional biomaterials to use in treatment, based on knowledge of cancer-specific molecular mechanisms. We hope to produce more information regarding functional biomaterials that can respond to cancer metastasis.

-->> see Functional collagen.